Document Detail

Influence of Thyroid State on Cardiac and Renal Capillary Density and Glomerular Morphology in Rats.
MedLine Citation:
PMID:  23048210     Owner:  NLM     Status:  Publisher    
Background: The purpose was to analyze the cardiac and renal capillary density and glomerular morphology that result from a chronic excess or deficiency of thyroid hormones in rats.Methods: We performed histopathological, morphometric and immunohistochemical analyses in hypothyroid and hyperthyroid rats to evaluate the density of mesenteric, renal and cardiac vessels at four weeks after induction of thyroid disorders. The main angiogenic factors in plasma and heart and kidney tissues were measured as possible mediators of vascular changes.Results: Mesenteric vessel branching was augmented and decreased in hyper- and hypothyroid rats, respectively. The numerical density of CD31-positive capillaries was higher in left and right ventricles and in cortical and medullar kidney from both hyper- and hypothyroid rats versus controls. The number of podocytes, glomeruli/mm2 and capillaries per glomerulus were similar in all groups, and no morphological renal lesions were observed in any group.Conclusions: Vascularization of the mesenteric bed is relative to the thyroid hormone levels, but an increased capillarity was observed in heart and kidney in both thyroid disorders. This greater capillarity may be produced by higher tissue levels of angiogenic factors in hypothyroid rats, whereas haemodynamic factors would be the main stimulus in hyperthyroid rats. Our results also indicate that the renal dysfunctions of thyroid disorders are not related to cortical or medullary microvascular rarefaction, and that the proteinuria of hyperthyroidism is not secondary to a deficit of podocytes. Finally, we propose that thyroid hormone or its analogues may be useful to increase capillarity in renal diseases associated with microvascular rarefaction.
Isabel Rodriguez; Inmaculada Banegas; Rosemary Wangensteen; Andrés Quesada; Rosario Jimenez; Mercedes Gómez-Morales; Francisco Ovalle; Juan Duarte; Félix Vargas
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-9
Journal Detail:
Title:  The Journal of endocrinology     Volume:  -     ISSN:  1479-6805     ISO Abbreviation:  J. Endocrinol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
I Rodriguez, Physiology, University of Granada, Granada, 18012, Spain.
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