Document Detail

Influence of Sildenafil on Micturition and Urethral Tone in Ovariectomized and Non-ovariectomized Mice.
MedLine Citation:
PMID:  22145776     Owner:  NLM     Status:  Publisher    
Introduction.  Nitric oxide synthases (NOSs) and estrogen receptors are expressed in the female urethra. Aim.  We aimed to assess the impact of sildenafil on micturition behavior, urethral tone according to the hormonal status and to determine the implications of the neuronal isoform of NOS (nNOS). Methods.  Four-week-old C57/BL6 female mice were sham-operated or ovariectomized. Six weeks later, they were injected intraperitoneally by any combination of sildenafil, 7-nitroindazole (7-NI)-a potent selective nNOS inhibitor-or the corresponding vehicles. The mice were then subjected to micturition behavior and leak point pressure studies. Urethral histomorphometry was performed. Main Outcome Measures.  The main outcome measures were micturition behavior, leak point pressure, and histomorphometry. Results.  In sham-operated and ovariectomized animals, sildenafil did not impact micturition, although it decreased urethral resistance 10-fold. nNOS inhibition by 7-NI reduced the number of micturitions and increased residual volume and leak point pressure. It abrogated sildenafil-induced drop in urethral resistances. Hormonal status did not influence the structure of the urethral layers. Conclusions.  Irrespective of the hormonal status, sildenafil decreased leak point pressure by a nNOS-mediated mechanism. Gamé X, Bouali O, Allard J, Gourdy P, Escourrou G, Tack I, Rischmann P, Arnal J-F, and Malavaud B. Influence of sildenafil on micturition and urethral tone in ovariectomized and non-ovariectomized mice. J Sex Med **;**:**-**.
Xavier Gamé; Ourdia Bouali; Julien Allard; Pierre Gourdy; Ghislaine Escourrou; Ivan Tack; Pascal Rischmann; Jean-François Arnal; Bernard Malavaud
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-6
Journal Detail:
Title:  The journal of sexual medicine     Volume:  -     ISSN:  1743-6109     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230693     Medline TA:  J Sex Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 International Society for Sexual Medicine.
Service d'Urologie, Transplantation Rénale et Andrologie, Centre Hospitalier Universitaire Rangueil, Toulouse, France Institut National de la Santé et de la Recherche Médicale U858 et Laboratoire de Physiologie, Toulouse, France Institut Fédératif de Recherche 31, Centre Hospitalier Universitaire Rangueil, Toulouse, France Laboratoire D'Anatomie Pathologique, Centre Hospitalier Universitaire Rangueil, Toulouse, France.
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