Document Detail


The Influence of Resistance Exercise Intensity and Metabolic Stress on Anabolic Signaling and the Expression of Myogenic Genes in Skeletal Muscle.
MedLine Citation:
PMID:  24916884     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Introduction: We investigated the effect of resistance exercise intensity and exercise-induced metabolic stress on the activation of anabolic signaling and expression of myogenic genes in skeletal muscle. Methods: 10 strength-trained athletes performed high-intensity [HI, 74% of 1 repetition maximum (RM)], middle-intensity (MI, 54% 1RM), or middle-intensity (54% 1RM) no-relaxation exercise (MIR). Kinase phosphorylation level and myogenic gene expression in muscle samples were evaluated before, 45 min, 5h, and 20 h after exercise. Results: The lactate concentration in MI was approximately 2-fold lower than in the 2 other sessions, and it was highest in MIR. The phosphorylation level of extracellular kinase 1/2(Thr202/Tyr204) after exercise was related to metabolic stress. Metabolic stress induced a decrease in myostatin mRNA expression, whereas mechano-growth factor mRNA level depended on exercise intensity. Conclusion: This study demonstrates that both intensity and exercise-induced metabolic stress can be manipulated to affect muscle anabolic signaling. © 2014 Wiley Periodicals, Inc.
Authors:
Daniil V Popov; Evgeny A Lysenko; Anton V Bachinin; Tatiana F Miller; Nadezda S Kurochkina; Irina V Kravchenko; Vladimir A Furalyov; Olga L Vinogradova
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-11
Journal Detail:
Title:  Muscle & nerve     Volume:  -     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Wiley Periodicals, Inc., a Wiley company.
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