Document Detail

Influence of propylthiouracil and methimazole pre-treatment on the outcome of iodine-131 therapy in hyperthyroid patients with Graves' disease.
MedLine Citation:
PMID:  19383254     Owner:  NLM     Status:  MEDLINE    
There is ongoing controversy about potential differences in the influence of the anti-thyroid drugs propylthiouracil (PTU) and methimazole (MMI) on radioiodine treatment of Graves' hyperthyroidism. This retrospective study investigated the influence of PTU and MMI pre-treatment, individually or sequentially, on the outcome of iodine-131 ((131)I) therapy in 199 patients with Graves' disease who had been treated with (131)I for the first time and followed up at 3 and 6 months after treatment. Pre-treatment with PTU, or sequential PTU and MMI pre-treatment, increased the failure rate of (131)I therapy and reduced the rate of hypothyroidism. MMI pre-treatment alone had no significant influence on the results of (131)I therapy. Logistic regression analyses indicated that PTU pre-treatment and having a thyroid gland of > 60 g were both significantly related to (131)I therapy failure.
G-M Shi; Q Xu; C-Y Zhu; Y-L Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of international medical research     Volume:  37     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2009 Mar-Apr
Date Detail:
Created Date:  2009-04-22     Completed Date:  2009-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  576-82     Citation Subset:  IM    
Department of Chemotherapy, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
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MeSH Terms
Graves Disease / drug therapy*
Iodine Radioisotopes
Methimazole / pharmacology,  therapeutic use*
Middle Aged
Propylthiouracil / pharmacology,  therapeutic use*
Regression Analysis
Thyroid Gland / drug effects,  pathology
Treatment Failure
Treatment Outcome
Reg. No./Substance:
0/Iodine Radioisotopes; 51-52-5/Propylthiouracil; 60-56-0/Methimazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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