Document Detail

The Influence of Peri-Incisional Triamcinolone Acetonide Injection on Wound Edge Apposition.
MedLine Citation:
PMID:  23210735     Owner:  NLM     Status:  Publisher    
Abstract Local administration of corticosteroids has been demonstrated to have both beneficial and detrimental effects on wound healing. The advantages of limiting localized edema must be weighed against corticosteroids' disadvantageous inhibition of the normal growth factor profile production that is essential for would healing. A single-center prospective, randomized, controlled, single-blind study of 57 patients undergoing hair restoration surgery by one of three different surgeons revealed: 1) No dehiscence along the donor wound; 2) No statistically-significant difference (p <0.05) in wound edge apposition noted between patients receiving or not receiving intralesional corticosteroids at any of the four measured scalp regions; and 3) A non-statistically-significant trend emerged suggesting the benefit of corticosteroid at the temples (points of decreased donor closing tension) versus its potential hinderance along the mastoids (points of increased tension). These results suggest that peri-incisional triamcinolone acetonide (PITMC) does not have a statistically-significant effect on donor wound edge apposition within 8 to 10 days of hair restoration surgery. A subtle, though not statistically significant, trend emerged demonstrating the benefit of PITMC with respect to early-phase donor wound edge apposition in areas of least donor closing tension and the hindrance of PITMC in regions of increased tension.
Carlos Knute Wesley; Lynn Hy Teo; Tina Xu; Robin H Unger; Walter P Unger
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-5
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  -     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Private Practice , New York , USA.
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