Document Detail

The Influence of Patterned Nanofiber Meshes on Human Mesenchymal Stem Cell Osteogenesis.
MedLine Citation:
PMID:  21485007     Owner:  NLM     Status:  Publisher    
A specially designed electroconductive collector enables the electrospinning of P-NFM composed of areas of parallel/uniaxially aligned fibers and areas of random/orthogonal nanofiber distribution. The biological relevance of P-NFM is demonstrated using hBMSCs as an autologous cell source. The structures induce cell orientation along the uniaxially aligned fibers, mainly during earlier culturing periods under basal and osteogenic differentiation conditions. The microtopography of the P-NFM also controls the deposition of mineralized extracellular matrix along the pre-defined fiber direction. Genotypic characterization confirms the successful differentiation into the osteogenic lineage.
Albino Martins; Marta L Alves da Silva; Susana Faria; Alexandra P Marques; Rui L Reis; Nuno M Neves
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-11
Journal Detail:
Title:  Macromolecular bioscience     Volume:  -     ISSN:  1616-5195     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135941     Medline TA:  Macromol Biosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
3B's Research Group, Biomaterials, Biodegradables and Biomimetics; Department of Polymer Engineering, University of Minho; Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra; S. Claudio do Barco; 4806-909 Caldas das Taipas, Guimarães; Portugal; IBB - Institute for Biotechnology and Bioengineering, PT Associated Laboratory, Braga, Portugal.
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