| Influence of PEG endgroup and molecular weight on its reactivity for lipase-catalyzed polyester synthesis. | |
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MedLine Citation:
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PMID: 16602719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polycondensations were performed at 70 degrees C in bulk using physically immobilized lipase B from Candida antarctica (CAL-B) as catalyst. Study of copolymerizations between sebacic acid and PEG diols of differing Mn values (200, 400, 600, 1000, 2000, and 10 000) showed that PEG 400 and 600 were most reactive (DP(avg) up to about 6). Increasing the PEG diol chain length from 600 to 1000, 2000, and 10 000 resulted in large decreases in copolymer DP(avg) values. PEG200 diacids (i.e., HOOC-(CH2)x-O-(CH2CH2O)n-(CH2)x-COOH) were successfully synthesized where x was 1, 4, 5, 7, 9, and 11. Study of copolymerizations of these diacids with 1,8-octanediol showed that, by introduction of a five-carbon methylene spacer (x = 5), remarkable increases in the reactivity of PEG200 diacids were achieved. In addition, introduction of this spacer was also effective for increasing the reactivity of PEG diacids of higher molecular weight (i.e., PEG400, 600, and 1000). This work verified the hypothesis that, by conversion of PEG chain ends to structures more closely resembling fatty acids, modified PEG building blocks are obtained that are better recognized as substrates by CAL-B during condensation reactions. |
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Authors:
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Bishwabhusan Sahoo; Anupam Bhattacharya; Hongyong Fu; Wei Gao; Richard A Gross |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Biomacromolecules Volume: 7 ISSN: 1525-7797 ISO Abbreviation: Biomacromolecules Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-10 Completed Date: 2006-07-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100892849 Medline TA: Biomacromolecules Country: United States |
Other Details:
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Languages: eng Pagination: 1042-8 Citation Subset: IM |
Affiliation:
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NSF I/UCRC of Biocatalysis and Bioprocessing of Macromolecules, Othmer Department of Chemical & Biological Sciences and Engineering, Polytechnic University, Brooklyn, New York 11201, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Candida
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enzymology Catalysis Lipase / chemistry* Molecular Weight Polyesters / chemical synthesis*, chemistry Polyethylene Glycols / chemistry* Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Polyesters; 0/Polyethylene Glycols; EC 3.1.1.-/lipase B, Candida antarctica; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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