| Influence of oral antidiabetic drugs on hyperglycemic response to foods in persons with type 2 diabetes mellitus as assessed by continuous glucose monitoring system: a pilot study. | |
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MedLine Citation:
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PMID: 20663465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The purpose of this prospective open-label trial was (1) to assess the influence of oral antidiabetic drugs (OAD) on the glycemic index (GI), glucose response curves (GRCs), daily mean plasma glucose (MPG) and (2) to compare the GI of foods in persons with OAD-treated type 2 diabetes mellitus (T2DM) with the respective GI in healthy persons (HP). METHODS: Tested foods containing 50 g of carbohydrates were eaten for breakfast and dinner after 10 and 4 h of fasting, respectively. Glycemic index, GRC, and MPG were obtained using the CGMS System Gold (CGMS). In T2DM patients [n = 16; age (mean +/- standard error) 56.0 +/- 2.25 years], foods were tested four times: tests 1, 2, and 3 were performed within one week in which placebo was introduced on day 2, and test 4 was carried out five weeks after reintroduction of OAD. Glycemic indexes, GRC, and MPG from tests 1, 2, 3, and 4 were compared. In a control group of 20 HP (age 24.4 +/- 0.71 years), the mean GIs were calculated as the mean from 20 subject-related GIs. RESULTS: In T2DM patients, subject-related assessment of GIs, GRC, and MPG distinguished persons with and without OAD effect. Nevertheless, the group-related GIs and the MPG on days 2, 8, and 39 showed no significant difference. There was no significant difference between the GIs in OAD-treated T2DM patients (test 4) versus HP (except in apple baby food). Glucose response curves were significantly larger in T2DM patients (test 4) versus HP. CONCLUSIONS: Determination of GRC and subject-related GI using the CGMS appears to be a potential means for the evaluation of efficacy of OAD treatment. Further studies are underway. |
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Authors:
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Peterson Karolina; Rudolf Chlup; Zapletalova Jana; Klaus Dieter Kohnert; Pavla Kudlova; Josef Bartek; Marie Nakladalova; Blanka Doubravova; Pavel Seckar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-01 |
Journal Detail:
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Title: Journal of diabetes science and technology Volume: 4 ISSN: 1932-2968 ISO Abbreviation: J Diabetes Sci Technol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-11-04 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 101306166 Medline TA: J Diabetes Sci Technol Country: United States |
Other Details:
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Languages: eng Pagination: 983-92 Citation Subset: IM |
Copyright Information:
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2010 Diabetes Technology Society. |
Affiliation:
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Department of Physiology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic. karolinapeterson@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Area Under Curve Blood Glucose / analysis Blood Glucose Self-Monitoring* Diabetes Mellitus, Type 2 / blood*, drug therapy* Dietary Carbohydrates / analysis Female Food Analysis Glycemic Index Hemoglobin A, Glycosylated Humans Hyperglycemia / drug therapy*, etiology Hypoglycemic Agents / administration & dosage, therapeutic use* Male Metformin / administration & dosage, therapeutic use Middle Aged Pilot Projects Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Carbohydrates; 0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 657-24-9/Metformin |
| Comments/Corrections | |
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