Document Detail

Influence of oral antidiabetic drugs on hyperglycemic response to foods in persons with type 2 diabetes mellitus as assessed by continuous glucose monitoring system: a pilot study.
MedLine Citation:
PMID:  20663465     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this prospective open-label trial was (1) to assess the influence of oral antidiabetic drugs (OAD) on the glycemic index (GI), glucose response curves (GRCs), daily mean plasma glucose (MPG) and (2) to compare the GI of foods in persons with OAD-treated type 2 diabetes mellitus (T2DM) with the respective GI in healthy persons (HP).
METHODS: Tested foods containing 50 g of carbohydrates were eaten for breakfast and dinner after 10 and 4 h of fasting, respectively. Glycemic index, GRC, and MPG were obtained using the CGMS System Gold (CGMS). In T2DM patients [n = 16; age (mean +/- standard error) 56.0 +/- 2.25 years], foods were tested four times: tests 1, 2, and 3 were performed within one week in which placebo was introduced on day 2, and test 4 was carried out five weeks after reintroduction of OAD. Glycemic indexes, GRC, and MPG from tests 1, 2, 3, and 4 were compared. In a control group of 20 HP (age 24.4 +/- 0.71 years), the mean GIs were calculated as the mean from 20 subject-related GIs.
RESULTS: In T2DM patients, subject-related assessment of GIs, GRC, and MPG distinguished persons with and without OAD effect. Nevertheless, the group-related GIs and the MPG on days 2, 8, and 39 showed no significant difference. There was no significant difference between the GIs in OAD-treated T2DM patients (test 4) versus HP (except in apple baby food). Glucose response curves were significantly larger in T2DM patients (test 4) versus HP.
CONCLUSIONS: Determination of GRC and subject-related GI using the CGMS appears to be a potential means for the evaluation of efficacy of OAD treatment. Further studies are underway.
Peterson Karolina; Rudolf Chlup; Zapletalova Jana; Klaus Dieter Kohnert; Pavla Kudlova; Josef Bartek; Marie Nakladalova; Blanka Doubravova; Pavel Seckar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-01
Journal Detail:
Title:  Journal of diabetes science and technology     Volume:  4     ISSN:  1932-2968     ISO Abbreviation:  J Diabetes Sci Technol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-11-04     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101306166     Medline TA:  J Diabetes Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  983-92     Citation Subset:  IM    
Copyright Information:
2010 Diabetes Technology Society.
Department of Physiology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic.
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MeSH Terms
Analysis of Variance
Area Under Curve
Blood Glucose / analysis
Blood Glucose Self-Monitoring*
Diabetes Mellitus, Type 2 / blood*,  drug therapy*
Dietary Carbohydrates / analysis
Food Analysis
Glycemic Index
Hemoglobin A, Glycosylated
Hyperglycemia / drug therapy*,  etiology
Hypoglycemic Agents / administration & dosage,  therapeutic use*
Metformin / administration & dosage,  therapeutic use
Middle Aged
Pilot Projects
Prospective Studies
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 657-24-9/Metformin

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