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Influence of ocular pulse amplitude on ocular response analyzer measurements.
MedLine Citation:
PMID:  20852442     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: To evaluate if the ocular pulse amplitude (OPA) (the difference between systolic and diastolic intraocular pressure) is associated with the measurement variability of IOPg [Goldmann-correlated intraocular pressure (IOP)], IOPcc (corneal compensated IOP), corneal hysteresis (CH), and corneal resistance factor (CRF) obtained from the ocular response analyzer (ORA).
METHODS: Sixty normal participants and 60 glaucoma patients were included. In 1 randomly selected eye in each participant, 4 repeated measurements were obtained with the ORA (Reichert Inc, Depew, NY) followed by OPA measurement by dynamic contour tonometry (Pascal; Swiss Microtechnology AG, Port, Switzerland). The repeatability of IOPg (a mathematically derived value with strong correlation with Goldmann applanation pressure measurement), IOPcc (a mathematically derived measurement less affected by corneal biomechanical properties), CH, and CRF were calculated. The associations between age, refraction, keratometry, central corneal thickness, axial length, OPA, and ORA measurements variability were evaluated with univariate and multivariate regression analyses.
RESULTS: The repeatability of IOPg, IOPcc, CRF, and CH were 4.08 (95% confidence interval: 3.06-5.09) mm Hg, 4.72 (3.54-5.89) mm Hg, 2.14 (1.61-2.68) mm Hg, 2.35 (1.77-2.94) mm Hg, respectively, for the normal group; and 4.18 (3.75-4.61) mm Hg, 5.56 (4.99-6.14) mm Hg, 2.17 (1.95-2.40) mm Hg, 2.78 (2.50-3.07) mm Hg, respectively, for the glaucoma group. Within-subject variances of IOPg and IOPcc, but not CRF and CH, were positively correlated with OPA. No association was found between age, refraction, keratometry, central corneal thickness, axial length, and the measurement variability of ORA.
CONCLUSIONS: The measurement reliability of ORA was only moderate. Eyes with large OPA were associated with high IOP measurement variability. Taking average of multiple repeated measurements is important for reliable measurement of ORA.
Guihua Xu; Dennis Shun Lam; Christopher Kai-Shun Leung
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of glaucoma     Volume:  20     ISSN:  1536-481X     ISO Abbreviation:  J. Glaucoma     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300903     Medline TA:  J Glaucoma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  344-9     Citation Subset:  IM    
*Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong †The STU/CUHK Joint Shantou International Eye Centre (JSIEC), Shantou University Medical College ‡HuiZhou Minicipal Central Hospital Eye Department, HuiZhou City, Guangdong Province, The People's Republic of China.
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