Document Detail

Influence of O2 deprivation, reduced flow, and temperature on release of ANP from rabbit hearts.
MedLine Citation:
PMID:  7611487     Owner:  NLM     Status:  MEDLINE    
The separate effects of hypoxia and ischemia on atrial natriuretic peptide (ANP) release were evaluated in Langendorff-perfused rabbit hearts. Heart rate, coronary flow, and atrial and ventricular volumes were kept constant. Hypoxia was induced for 20 min at room temperature in seven hearts and at 37 degrees C in a second group of seven hearts. A third group of eight hearts was subjected to global ischemia for 20 min by reducing coronary flow to 1 ml/min at room temperature. All hearts were reoxygenated/reperfused at 37 degrees C for 30 min. Hypoxia at 37 degrees C induced a significant increase in ANP release. In contrast, both room temperature hypoxia and ischemia were characterized by a significant decrease in ANP release, despite hemodynamic alterations similar to those recorded during hypoxia at 37 degrees C. Both reoxygenation and reperfusion induced a prompt reversal of the changes of ANP release observed during the period of oxygen deprivation. These data demonstrate that decreased oxygen availability and reduced coronary flow are not the primary factors affecting release of ANP during ischemia and that alterations of myocardial temperature may play a major role in this phenomenon.
A Focaccio; G Ambrosio; I Enea; R Russo; P Balestrieri; M Chiariello; M Volpe
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  268     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-08-14     Completed Date:  1995-08-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H2352-7     Citation Subset:  IM    
Department of Medicine, Federico II School of Medicine, Naples, Italy.
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MeSH Terms
Anoxia / physiopathology*
Atrial Natriuretic Factor / metabolism*
Coronary Circulation
Heart / physiology*,  physiopathology*
Heart Rate
Myocardial Ischemia / physiopathology*
Myocardial Reperfusion
Time Factors
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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