Document Detail


The influence of nutrigenetics on the lipid profile: interaction between genes and dietary habits.
MedLine Citation:
PMID:  20091341     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nutrigenetics is a new field with few studies in Latin America. Our aim is to investigate the way in which different genes related to the lipid profile influence the response to specific dietary habits. Eight polymorphisms on seven genes were investigated in a sample (n = 567) from Porto Alegre, RS, Brazil. All the volunteers completed a food diary that was then assessed and classified into nine food groups. A number of nutrigenetic interactions were detected primarily related to the apolipoprotein E (apoE) gene. For example, frequent consumption of foods rich in polyunsaturated fat resulted in the beneficial effect of increasing HDL-C only in individuals who were not carriers of the E*4 allele of the APOE gene, whereas variations in eating habits of E*4 carriers did not affect their HDL-C (P = 0.018). Our data demonstrate for the first time nutrigenetic interactions in a Brazilian population.
Authors:
Fabiana M de Andrade; Andr?a C Bulh?es; Sharbel W Maluf; Jaqueline B Schuch; Francine Voigt; Juliana F Lucatelli; Alessandra C Barros; Mara H Hutz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-21
Journal Detail:
Title:  Biochemical genetics     Volume:  48     ISSN:  1573-4927     ISO Abbreviation:  Biochem. Genet.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-11     Completed Date:  2010-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0126611     Medline TA:  Biochem Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  342-55     Citation Subset:  IM    
Affiliation:
Health Sciences Institute, Centro Universit?rio Feevale, RS 239, No. 2755, B. Vila Nova, Novo Hamburgo, RS CEP 93352-000, Brazil. fabiana.andrade@feevale.br
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Apolipoproteins E / genetics
Diet Surveys
Epistasis, Genetic / physiology*
Female
Food Habits / physiology*
Humans
Lipid Metabolism / genetics*
Lipids / blood*
Male
Metabolome / genetics
Middle Aged
Nutrigenomics*
Questionnaires
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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