Document Detail

The Influence of Neocate in Paediatric Short Bowel Syndrome on PN Weaning.
MedLine Citation:
PMID:  20721339     Owner:  NLM     Status:  In-Data-Review    
Clinical management of short bowel syndrome remains a multistage process. Although PN is crucial, early introduction of enteral feeding is mandatory. We describe retrospectively 4 patients with an ultrashort bowel who could be weaned off PN on very short terms after introduction of an amino-acid-based formula (Neocate). Patient 1 had congenital short bowel with 50 cm small bowel and 30 cm colon. He had persistent diarrhoea on a semielementary formula. When Neocate was introduced he could be weaned from PN within 6 months. Patient 2 needed multiple surgical interventions because of NEC at D 27. He maintained 40 cm small bowel and an intact colon and remained PN dependent on semielemental formula. After introducing Neocate, PN could be weaned within 3 months. In the next 2 patients, Neocate was introduced as initial enteral feeding after bowel resection following antenatal midgut volvulus. Patient 3 had 20 cm small bowel and an intact colon. PN was weaned after 2 months. Patient 4 had 9 cm small bowel and an intact colon. PN was weaned after 13 months. In all patients Ileocaecal valve (ICV) was preserved. No consensus is reached on the type of formula to use for short bowel syndrome. Compared to recent data in the literature, the weaning period in these 4 patients was significantly shortened on an aminoacid based formula. The reason for this may lie in the antiallergic properties of this formula. We recommend the use of an amino-acid-based formula to induce earlier weaning of PN.
E De Greef; T Mahler; A Janssen; H Cuypers; G Veereman-Wauters
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Publication Detail:
Type:  Journal Article     Date:  2010-05-31
Journal Detail:
Title:  Journal of nutrition and metabolism     Volume:  2010     ISSN:  2090-0732     ISO Abbreviation:  J Nutr Metab     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101526296     Medline TA:  J Nutr Metab     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  -    
Queen Paola Children's Hospital ZNA, Antwerp, Belgium.
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