| Influence of Moringa oleifera on pharmacokinetic disposition of rifampicin using HPLC-PDA method: a pre-clinical study. | |
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MedLine Citation:
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PMID: 20845375 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The influence of active fraction isolated from pods of an indigenous plant, Moringa oleifera (MoAF) was studied on the pharmacokinetic profile of the orally administered frontline anti-tuberculosis drug rifampicin (20 mg/kg b.w.) in Swiss albino mice. The antibiotic rifampicin alone and in combination with MoAF (0.1 mg/kg b.w.) was administered orally and heparanized blood samples were collected from the orbital plexus of mice for plasma separation at 0, 1, 2, 3, 4 and 5 h, post treatment. Plasma rifampicin concentration, pharmacokinetic parameters and drug metabolizing enzyme (cytochrome P-450) activity were determined. The pharmacokinetic data revealed that MoAF-treated animals had significantly increased rifampicin plasma concentration, C(max) , K(el) , t(½(a)) , t(½(el)) , K(a) and AUC as well as inhibited rifampicin-induced cytochrome P-450 activity. In conclusion, the result of this study suggested that the bioavailability-enhancing property of MoAF may help to lower the dosage level and shorten the treatment course of rifampicin. Copyright © 2010 John Wiley & Sons, Ltd. |
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Authors:
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Anirban Pal; Dnyaneshwar Umrao Bawankule; Mahendra Pandurang Darokar; Subhash Chandra Gupta; Jai Shankar Arya; Karuna Shanker; Madan Mohan Gupta; Narayan Prasad Yadav; Suman Preet Singh Khanuja |
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Publication Detail:
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Type: Journal Article Date: 2010-09-15 |
Journal Detail:
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Title: Biomedical chromatography : BMC Volume: 25 ISSN: 1099-0801 ISO Abbreviation: Biomed. Chromatogr. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610241 Medline TA: Biomed Chromatogr Country: England |
Other Details:
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Languages: eng Pagination: 641-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Division of Molecular Bioprospection, Central Institute of Medicinal and Aromatic Plants, CSIR, Lucknow-226015, India. a.pal@cimap.res.in. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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