| Influence of Lipid Type on Bis (2-ethylhexyl)phthalate (DEHP) Leaching From Infusion Line Sets in Parenteral Nutrition. | |
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MedLine Citation:
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PMID: 21868720 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Bis(2-ethylhexyl)phthalate (or DEHP) is widely used in polyvinyl chloride (PVC) tubings for its good plasticizing properties. Because it is not covalently bound to the plastic matrix, it is able to escape from PVC during the infusion of the lipid emulsions used in parenteral nutrition (PN). This creates a vector through which it can enter into contact with the patient via the nutrition admixtures infused. This study was designed to assess the potential role of the type of lipids used in PN admixtures on the quantity of DEHP leached out from PVC-based tubings. METHODS: PVC-based infusion lines, 6 commercially available lipid emulsions, and their oil base components were left in direct contact, and the amount of DEHP leached was measured by liquid chromatography. RESULTS: After a 24-hour exposure period, DEHP migration varied significantly (P = .0000152) according to lipid type. The olive oil-based emulsion Clinoleic leached the most DEHP (65.8 μg/mL intravenous fat emulsion), followed by the fish oil-based emulsion Omegaven (37.8 μg/mL). The soybean oil-based emulsions Intralipid, Medialipide, Lipidem, and Structolipid showed comparable performances, with DEHP leaching rates into the emulsion measured at 27.3, 27.8, 23.6, and 19.6 μg/mL, respectively. Results from the same experiments run on pure-form oils (soybean oil, olive oil, coconut oil, and cod liver oil) confirmed the influence of lipid type on DEHP leaching. Conclusion: The major DEHP leaching caused by olive oil-based emulsions raises cause for concern because DEHP presents distinctive toxic effects, including an increased risk of cholestasis. (JPEN J Parenter Enteral Nutr. XXXX;xx:xx-xx). |
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Authors:
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Sandrine Bagel; Bérangère Dessaigne; Daniel Bourdeaux; Anne Boyer; Corinne Bouteloup; Jean-Etienne Bazin; Jean Chopineau; Valérie Sautou |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-25 |
Journal Detail:
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Title: JPEN. Journal of parenteral and enteral nutrition Volume: - ISSN: 0148-6071 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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G. Montpied Hospital. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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