| Influence of lineage-specific amino acid dimorphisms in GyrA on Mycobacterium tuberculosis resistance to fluoroquinolones. | |
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MedLine Citation:
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PMID: 22274162 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We conducted in vitro DNA supercoiling assays, utilizing recombinant DNA gyrases, to elucidate the influence of the lineage-specific serine or threonine residue at position 95 of GyrA on fluoroquinolone resistance in Mycobacterium tuberculosis. There was little effect of the GyrA-Ala74Ser amino acid substitution on activity of the GyrA-Ser95 gyrase, while activity of the GyrA-Asp94Gly-Ser95 gyrase was reduced. These findings were in striking contrast to previous reports analyzing GyrA with Thr95 and suggest an important impact of the amino acid in the development of fluoroquinolone resistance. |
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Authors:
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Hyun Kim; Chie Nakajima; Youn Uck Kim; Kazumasa Yokoyama; Yasuhiko Suzuki |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Japanese journal of infectious diseases Volume: 65 ISSN: 1884-2836 ISO Abbreviation: Jpn. J. Infect. Dis. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-25 Completed Date: 2012-05-17 Revised Date: 2012-07-16 |
Medline Journal Info:
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Nlm Unique ID: 100893704 Medline TA: Jpn J Infect Dis Country: Japan |
Other Details:
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Languages: eng Pagination: 72-4 Citation Subset: IM |
Affiliation:
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Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Substitution* DNA Gyrase / genetics, metabolism* DNA, Bacterial / genetics DNA, Superhelical / genetics Drug Resistance, Bacterial Enzyme Activation Escherichia coli / genetics, metabolism Fluoroquinolones / pharmacology* Microbial Sensitivity Tests Mycobacterium tuberculosis / drug effects*, enzymology*, genetics Plasmids / genetics, metabolism Recombinant Proteins / genetics, metabolism Serine / genetics, metabolism Threonine / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/DNA, Bacterial; 0/DNA, Superhelical; 0/Fluoroquinolones; 0/Recombinant Proteins; 56-45-1/Serine; 72-19-5/Threonine; EC 5.99.1.-/DNA Gyrase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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