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Influence of Lightweight Ambulatory Oxygen on Oxygen Use and Activity Patterns of COPD Patients Receiving Long-Term Oxygen Therapy.
MedLine Citation:
PMID:  22292592     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract Lightweight ambulatory oxygen devices are provided on the assumptions that they enhance compliance and increase activity, but data to support these assumptions are lacking. We studied 22 patients with severe chronic obstructive pulmonary disease receiving long-term oxygen therapy (14 men, average age = 66.9 y, FEV(1) = 33.6%pred, PaO(2) at rest = 51.7 torr) who were using E-cylinders as their portable oxygen. Subjects were recruited at 5 sites and studied over a 2-week baseline period and for 6 months after randomizing them to either continuing to use 22-lb E-cylinders towed on a cart or to carrying 3.6-lb aluminum cylinders. Utilizing novel electronic devices, ambulatory and stationary oxygen use was monitored continuously over the 2 weeks prior to and the 6 months following randomization. Subjects wore tri-axial accelerometers to monitor physical activity during waking hours for 2-3 weeks prior to, and at 3 and 6 months after, randomization. Seventeen subjects completed the study. At baseline, subjects used 17.2 hours of stationary and 2.5 hours of ambulatory oxygen daily. At 6 months, ambulatory oxygen use was 1.4 ± 1.0 hrs in those randomized to E-cylinders and 1.9 ± 2.4 hrs in those using lightweight oxygen (P = NS). Activity monitoring revealed low activity levels prior to randomization and no significant increase over time in either group. In this group of severe chronic obstructive pulmonary disease patients, providing lightweight ambulatory oxygen did not increase either oxygen use or activity. Future efforts might focus on strategies to encourage oxygen use and enhance activity in this patient group. This trial is registered at ClinicalTrials.gov (NCT003257540).
Authors:
Richard Casaburi; Janos Porszasz; Ariel Hecht; Brian Tiep; Richard K Albert; Nicholas R Anthonisen; William C Bailey; John E Connett; J Allen Cooper; Gerard J Criner; Jeffrey Curtis; Mark Dransfield; Stephen C Lazarus; Barry Make; Fernando J Martinez; Charlene McEvoy; Dennis E Niewoehner; John J Reilly; Paul Scanlon; Steven M Scharf; Frank C Sciurba; Prescott Woodruff; For The Copd Clinical Research Network
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  COPD     Volume:  9     ISSN:  1541-2563     ISO Abbreviation:  COPD     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101211769     Medline TA:  COPD     Country:  England    
Other Details:
Languages:  eng     Pagination:  3-11     Citation Subset:  IM    
Affiliation:
1Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center , Torrance, California , USA.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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