Document Detail

Influence of LVAD Cannula Outflow Tract Location on Hemodynamics in the Ascending Aorta: A Patient-Specific Computational Fluid Dynamics Approach.
MedLine Citation:
PMID:  23013842     Owner:  NLM     Status:  Publisher    
To develop a better understanding of the hemodynamic alterations in the ascending aorta, induced by variation of the cannula outflow position of the left ventricular assist device (LVAD) device based on patient-specific geometries, transient computational fluid dynamics (CFD) simulations using the realizable k-ε turbulent model were conducted for two of the most common LVAD outflow geometries. Thoracic aortic flow patterns, pressures, wall shear stresses (WSSs), turbulent dissipation, and energy were quantified in the ascending aorta at the location of the cannula outflow. Streamlines for the lateral geometry showed a large region of disturbed flow surrounding the LVAD outflow with an impingement zone at the contralateral wall exhibiting increased WSSs and pressures. Flow disturbance was reduced for the anterior geometries with clearly reduced pressures and WSSs. Turbulent dissipation was higher for the lateral geometry and turbulent energy was lower. Variation in the position of the cannula outflow clearly affects hemodynamics in the ascending aorta favoring an anterior geometry for a more ordered flow pattern. The new patient-specific approach used in this study for LVAD patients emphasizes the potential use of CFD as a truly translational technique.
Christof Karmonik; Sasan Partovi; Matthias Loebe; Bastian Schmack; Ali Ghodsizad; Mark R Robbin; George P Noon; Klaus Kallenbach; Matthias Karck; Mark G Davies; Alan B Lumsden; Arjang Ruhparwar
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-25
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  -     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the *DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, TX; †Department of Cardiac Surgery, University Hospital of Heidelberg, Heidelberg, Germany; and ‡Department of Radiology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH.
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