| Influence of L-rhamnosyl-D-glucosyl derivatives on properties and biological interaction of flavonoids. | |
| | |
MedLine Citation:
|
PMID: 18987944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The anti-proliferative activity of hesperetin, hesperidin, neohesperidin and rutin was evaluated on human hepatoma cell lines (Hep G2) and correlated to their antioxidant activity. The results obtained showed strong anti-proliferative effects of hesperidin and neohesperidin, considerably higher than the other two additives. Hesperetin induced caspase-3 activation, release of LDH and endogenous accumulation of putrescine. Cell cycle distribution seems to indicate that the inhibitory effects of polyphenols on cell growth could be due to G0/G1 block, and activation of apoptotic pathway in the presence of hesperetin. Our results underline also that the glycone forms show reduced scavenging activity against DPPH, but present a remarkable inhibition of cell proliferation and low cytotoxicity. |
| | |
Authors:
|
Ersilia Bellocco; Davide Barreca; Giuseppina Laganà; Ugo Leuzzi; Ester Tellone; Silvana Ficarra; Arnost Kotyk; Antonio Galtieri |
Related Documents
:
|
11557774 - The peroxisome proliferator-activated receptor delta promotes lipid accumulation in hum... 17681144 - Macrophage polarization and insulin resistance: ppargamma in control. 16142324 - In vitro inhibition of matriptase prevents invasive growth of cell lines of prostate an... 16330064 - Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinf... 12421674 - Cytokine regulation of liver development. 21171524 - The counter-regulation of atherogenesis: a role for interleukin-33. |
Publication Detail:
|
Type: Journal Article Date: 2008-11-06 |
Journal Detail:
|
Title: Molecular and cellular biochemistry Volume: 321 ISSN: 1573-4919 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2009-01-09 Completed Date: 2009-11-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 165-71 Citation Subset: IM |
Affiliation:
|
Department of Organic and Biological Chemistry, University of Messina, Messina, Italy. bellocco@isengard.unime.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apoptosis / drug effects Biological Markers / metabolism Biphenyl Compounds / metabolism Caspase 3 / metabolism Cell Line, Tumor / drug effects* Cell Proliferation / drug effects Flavonoids* / chemistry, metabolism, pharmacology Free Radicals / metabolism Hesperidin* / chemistry, metabolism, pharmacology Humans Picrates / metabolism Polyamines / metabolism Rutin* / chemistry, metabolism, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Biphenyl Compounds; 0/Flavonoids; 0/Free Radicals; 0/Picrates; 0/Polyamines; 153-18-4/Rutin; 1898-66-4/2,2-diphenyl-1-picrylhydrazyl; 520-26-3/Hesperidin; 520-33-2/hesperetin; EC 3.4.22.-/Caspase 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Use of simultaneous angioplasty and in situ thrombolysis with a specialized balloon catheter for per...
Next Document: Influence of nanofibers on the growth and osteogenic differentiation of stem cells: a comparison of ...