| Influence of L-carnitine and its derivatives on myocardial metabolism and function in ischemic heart disease and during cardiopulmonary bypass. | |
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MedLine Citation:
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PMID: 11399244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carnitine and its derivatives have recently been shown to protect cardiac metabolism and function in ischemic heart disease and other clinical conditions of myocardial ischemia. Potential mechanisms of this effect include an increase in glucose metabolism, a reduction of toxic effects of long-chain acyl-CoA and acyl-carnitine in myocytes, an increase in coronary blood flow and anti-arrhythmic effect. It has also been shown that propionyl-L-carnitine which penetrates faster than carnitine into myocytes is effective in inhibiting production of free radicals. Beneficial effects of carnitine supplementation have been demonstrated under a variety of clinical conditions such as acute cardiac ischemia, during extracorporeal circulation, in carnitine-dependent cardiomyopathy as well as in patients with chronic circulatory failure and in cardiogenic shock. However, further studies are required before carnitine administration could be recommended as a routine procedure in ischemic heart disease or before cardiopulmonary bypass. |
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Authors:
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R Lango; R T Smolenski; M Narkiewicz; J Suchorzewska; W Lysiak-Szydlowska |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardiovascular research Volume: 51 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-06-11 Completed Date: 2001-08-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 21-9 Citation Subset: IM |
Affiliation:
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Chair and Department of Anesthesiology and Intensive Care, Medical University of Gdańsk, Debinki 80-211, Gdańsk, Poland. rlango@amg.gda.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Arrhythmias, Cardiac / drug therapy, metabolism Cardiopulmonary Bypass* Carnitine / analogs & derivatives*, deficiency, metabolism*, therapeutic use Energy Metabolism Glucose / metabolism Humans Kidney / metabolism Myocardial Ischemia / drug therapy, metabolism* Myocardium / metabolism* Thrombosis / drug therapy, metabolism |
| Chemical | |
Reg. No./Substance:
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17298-37-2/propionylcarnitine; 50-99-7/Glucose; 541-15-1/Carnitine; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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