| Influence of L-3-methoxytyrosine on monoamine synthesis in rat brain. | |
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MedLine Citation:
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PMID: 1081656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats were injected i.p. with L-3-methoxytyrosine, 100 or 300 mg/kg. One h later brain, liver, heart and blood plasma were analyzed for catecholamines and their precursors. In brain Dopa as well as dopamine and noradrenaline levels were unchanged, while demethylation of L-3-methoxytyrosine might have occurred in peripheral organs since Dopa levels in liver and dopamine in heart were elevated. 3-Methoxytyramine could not be detected in brain and liver after treatment with L-3-methoxytyrosine. Monoamine synthesis in vivo was measured in whole brain by determining the accumulation of Dopa and 5-hydroxytryptophan 30 min after the i.p. injection of NSD 1015(3-hydroxybenzylhydrazine HC1, 100 mg/kg), an inhibitor of the aromatic amino acid decarboxylase. L-3-Methoxytyrosine attenuated the formation of Dopa and 5-hydroxytryptophan by about 25% in brain tissue. The effect was paralleled by a decrease in the brain concentration of tryptophan. |
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Authors:
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W Kehr |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 290 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1975 |
Date Detail:
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Created Date: 1976-02-09 Completed Date: 1976-02-09 Revised Date: 2010-03-12 |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 347-56 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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5-Hydroxytryptophan
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biosynthesis Animals Biogenic Amines / biosynthesis* Brain / drug effects, metabolism* Dihydroxyphenylalanine / biosynthesis Dopamine / biosynthesis Hydrazines / pharmacology Hydroxyindoleacetic Acid / biosynthesis Levodopa / metabolism Liver / metabolism Male Myocardium / metabolism Norepinephrine / biosynthesis Rats Serotonin / biosynthesis Tryptophan / biosynthesis Tyrosine / analogs & derivatives*, biosynthesis, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Biogenic Amines; 0/Hydrazines; 0/Levodopa; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid; 55520-40-6/Tyrosine; 56-69-9/5-Hydroxytryptophan; 63-84-3/Dihydroxyphenylalanine; 73-22-3/Tryptophan |
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