Document Detail

Influence of L-3-methoxytyrosine on monoamine synthesis in rat brain.
MedLine Citation:
PMID:  1081656     Owner:  NLM     Status:  MEDLINE    
Rats were injected i.p. with L-3-methoxytyrosine, 100 or 300 mg/kg. One h later brain, liver, heart and blood plasma were analyzed for catecholamines and their precursors. In brain Dopa as well as dopamine and noradrenaline levels were unchanged, while demethylation of L-3-methoxytyrosine might have occurred in peripheral organs since Dopa levels in liver and dopamine in heart were elevated. 3-Methoxytyramine could not be detected in brain and liver after treatment with L-3-methoxytyrosine. Monoamine synthesis in vivo was measured in whole brain by determining the accumulation of Dopa and 5-hydroxytryptophan 30 min after the i.p. injection of NSD 1015(3-hydroxybenzylhydrazine HC1, 100 mg/kg), an inhibitor of the aromatic amino acid decarboxylase. L-3-Methoxytyrosine attenuated the formation of Dopa and 5-hydroxytryptophan by about 25% in brain tissue. The effect was paralleled by a decrease in the brain concentration of tryptophan.
W Kehr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  290     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1975  
Date Detail:
Created Date:  1976-02-09     Completed Date:  1976-02-09     Revised Date:  2010-03-12    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  347-56     Citation Subset:  IM    
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MeSH Terms
5-Hydroxytryptophan / biosynthesis
Biogenic Amines / biosynthesis*
Brain / drug effects,  metabolism*
Dihydroxyphenylalanine / biosynthesis
Dopamine / biosynthesis
Hydrazines / pharmacology
Hydroxyindoleacetic Acid / biosynthesis
Levodopa / metabolism
Liver / metabolism
Myocardium / metabolism
Norepinephrine / biosynthesis
Serotonin / biosynthesis
Tryptophan / biosynthesis
Tyrosine / analogs & derivatives*,  biosynthesis,  pharmacology
Reg. No./Substance:
0/Biogenic Amines; 0/Hydrazines; 0/Levodopa; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid; 55520-40-6/Tyrosine; 56-69-9/5-Hydroxytryptophan; 63-84-3/Dihydroxyphenylalanine; 73-22-3/Tryptophan

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