| The influence of high-intensity moderate duration exercise on cardiac troponin I and C-reactive protein in sled dogs. | |
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MedLine Citation:
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PMID: 20840303 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: C-reactive protein (CRP) and cardiac troponin I (cTnI) are biomarkers of systemic inflammation and cardiac damage, respectively. OBJECTIVE: To investigate the effects of short-duration high-intensity exercise on plasma cTnI and serum CRP concentrations in sprint racing sled dogs. ANIMALS: Twenty-two Alaskan sled dogs of 2 different teams participating in a 2-day racing event. METHODS: In this prospective field study, cephalic venipuncture was performed on all dogs before racing and immediately after racing on 2 consecutive days. Plasma cTnI and serum CRP concentrations were evaluated at each time point. RESULTS: There was a mild, significant rise (P<.01) in median cTnI concentrations from resting (0.02 ng/mL; 0.0-0.12 ng/mL) on both days after racing (day 1=0.06, 0.02-0.2 ng/mL; day 2=0.07, 0.02-0.21 ng/mL). Serum CRP concentrations showed a mild significant increase (P<.01) on day 2 after racing mean (9.2±4.6 μg/mL) as compared with resting (6.5+4.3 μg/mL) and day 1 after racing (5.0+2.9 μg/mL). Neither cTnI or CRP concentrations exceeded the upper reference range for healthy dogs. CONCLUSIONS AND CLINICAL RELEVANCE: Strenuous exercise of short duration did not result in cTnI concentrations above the reference range for healthy dogs. Although increased after 2 days of short-duration strenuous exercise, CRP did not reach concentrations suggestive of inflammation, as reported previously in the endurance sled dogs. Therefore, we surmise that moderate exercise does not present a confounding variable in the interpretation of cTnI and CRP concentrations in normal dogs. |
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Authors:
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J J Wakshlag; M S Kraus; A R Gelzer; R L Downey; P Vacchani |
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Publication Detail:
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Type: Journal Article Date: 2010-09-14 |
Journal Detail:
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Title: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine Volume: 24 ISSN: 0891-6640 ISO Abbreviation: J. Vet. Intern. Med. Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708660 Medline TA: J Vet Intern Med Country: United States |
Other Details:
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Languages: eng Pagination: 1388-92 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 by the American College of Veterinary Internal Medicine. |
Affiliation:
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Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. dr.joesh@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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