Document Detail

Influence of Helicobacter pylori on gastric regulation of food intake.
MedLine Citation:
PMID:  19584718     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To evaluate the influence of Helicobacter pylori infection on the gastric regulation of food intake and body weight. RECENT FINDINGS: H. pylori infection leads to a decrease of circulating ghrelin through a reduction of ghrelin-producing cells in the gastric mucosa and increases the amount of gastric leptin with no effect on circulating leptin levels. Eradication of H. pylori reverses the abnormal regulation of gastric hormone secretion. This finding is suggested to favor weight gain after H. pylori eradication and points to the potential effect of H. pylori in the pathophysiology of obesity. SUMMARY: H. pylori has an influence on the release of gastric hormones and therefore plays a role in the regulation of body weight, hunger and satiety.
Jochen Weigt; Peter Malfertheiner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  12     ISSN:  1535-3885     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-04     Completed Date:  2009-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  522-5     Citation Subset:  IM    
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-v.-Guericke University Magdeburg, Magdeburg, Germany.
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MeSH Terms
Appetite / physiology*
Body Weight / physiology
Gastric Mucosa / metabolism,  physiopathology
Gastritis / metabolism,  physiopathology*
Ghrelin / metabolism,  physiology
Helicobacter Infections / metabolism,  physiopathology*
Helicobacter pylori*
Homeostasis / physiology
Leptin / metabolism,  physiology
Reg. No./Substance:
0/Ghrelin; 0/Leptin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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