Document Detail


Influence of HMB Supplementation and Resistance Training on Cytokine Responses to Resistance Exercise.
MedLine Citation:
PMID:  25140763     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Purpose: The purpose of this study was to determine the effects of a multinutritional supplement including amino acids, β-hydroxy-β-methylbutyrate (HMB), and carbohydrates on cytokine responses to resistance exercise and training. Methods: Seventeen healthy, college-aged men were randomly assigned to a Muscle Armor™ (MA; Abbott Nutrition, Columbus, OH) or placebo supplement group and 12 weeks of resistance training. An acute resistance exercise protocol was administered at 0, 6, and 12 weeks of training. Venous blood samples at pre-, immediately post-, and 30-minutes postexercise were analyzed via bead multiplex immunoassay for 17 cytokines. Results: After 12 weeks of training, the MA group exhibited decreased interferon-gamma (IFN-γ) and interleukin (IL)-10. IL-1β differed by group at various times. Granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, IL-7, IL-8, IL-12p70, IL-13, IL-17, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-1 beta (MIP-1β) changed over the 12-week training period but did not differ by group. Conclusions: Twelve weeks of resistance training alters the cytokine response to acute resistance exercise, and supplementation with HMB and amino acids appears to further augment this result.
Authors:
William J Kraemer; Disa L Hatfield; Brett A Comstock; Maren S Fragala; Patrick M Davitt; Cristina Cortis; Jacob M Wilson; Elaine C Lee; Robert U Newton; Courtenay Dunn-Lewis; Keijo Häkkinen; Tunde K Szivak; David R Hooper; Shawn D Flanagan; David P Looney; Mark T White; Jeff S Volek; Carl M Maresh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-20
Journal Detail:
Title:  Journal of the American College of Nutrition     Volume:  -     ISSN:  1541-1087     ISO Abbreviation:  J Am Coll Nutr     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8215879     Medline TA:  J Am Coll Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-9     Citation Subset:  -    
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