Document Detail

Influence of HIV-1 infection on GBV-C infection in multiply infected haemophilic patients.
MedLine Citation:
PMID:  9829635     Owner:  NLM     Status:  MEDLINE    
Two hundred thirteen haemophilic patients were studied for the presence of GBV-C RNA and anti-E2 antibodies soon after their first treatment with unsterilised factor concentrates and in their most recent sample. An assessment was made to determine whether coinfection with HIV had any effect on the progression of GBV-C infection. All of the patients were infected with HCV and 81 patients (37%) were also infected with HIV. GBV-C RNA was detected using the Abbott LCx(TM) assay and by RT-PCR. Anti-E2 antibodies were detected using the microPLATE Anti-HGenv assay and by Abbott Laboratories. The HIV-negative patients were more likely than the HIV-positive patients to lose GBV-C RNA between the two time points. A proportion of the patients lost their anti-E2 antibodies over the time period, however, the majority of these were HIV-positive. This study shows that infection with HIV does affect the progression of GBV-C infection, however, this effect is little understood as yet.
H Devereux; C A Sabin; Z Kinson; D Brown; A Griffioen; G M Dusheiko; C A Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical virology     Volume:  56     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-02-11     Completed Date:  1999-02-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  316-20     Citation Subset:  IM; X    
Department of Retrovirology, Royal Free Hospital, London, England.
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MeSH Terms
Disease Progression
Flaviviridae* / immunology,  isolation & purification
HIV Infections / complications*,  immunology
Hemophilia A / complications*
Hepatitis Antibodies / blood
Hepatitis, Viral, Human / complications*,  immunology,  virology
RNA, Viral / blood
Reverse Transcriptase Polymerase Chain Reaction
Viral Envelope Proteins / immunology
Reg. No./Substance:
0/Hepatitis Antibodies; 0/RNA, Viral; 0/Viral Envelope Proteins; 0/glycoprotein E2, GB virus C

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