| Influence of Glutathione on the Electroretinogram in Diabetic and Non-diabetic Rats. | |
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MedLine Citation:
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PMID: 21851169 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aims: The purpose of this study was to investigate the influence of glutathione on the electroretinogram (ERG) in diabetic and non-diabetic rats. Materials and Methods: Streptozotocin (STZ: 60 mg/kg) was injected into male RCC Wistar rats to induce hyperglycemia, with buffer instead of STZ injected into age-matched non-diabetic controls. After 8 weeks, ERG measurements were obtained at seven different scotopic flash intensities on the two groups of anesthetized, dark-adapted rats (controls, STZ). Following ERG measurements, eyes were enucleated for measurements of retinal/vitreous GSH and glutathione disulfide (GSSG). Results: Diabetic rats produced delayed b-wave ERG signals (increased implicit times), but had normal a-wave and b-wave amplitudes, a-wave implicit times, and oscillatory potentials. No differences were observed in retinal GSH or GSSG between controls and diabetics; however, correlations between GSH and all ERG parameters (with the exception of b-wave implicit times) were noted, and were not significantly altered by the presence of hyperglycemia. Conclusions: GSH is likely to play an important role in retinal function as assessed by the ERG, with this role not substantially altered in rats diabetic for 8 weeks. |
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Authors:
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William S Wright; Robert M McElhatten; Carmina Busu; Singh Yadav Amit; Wendy Leskova; Tak Yee Aw; Norman R Harris |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current eye research Volume: 36 ISSN: 1460-2202 ISO Abbreviation: Curr. Eye Res. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8104312 Medline TA: Curr Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 831-7 Citation Subset: IM |
Affiliation:
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Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center , Shreveport, Louisiana , USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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