| The influence of gemfibrozil on malondialdehyde level and paraoxonase 1 activity in wistar and fisher rats. | |
| | |
MedLine Citation:
|
PMID: 21223511 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
There are diverse experimental data about the influence of gemfibrozil (GEM) on the production of hydrogen peroxide (H(2)O(2)) and antioxidant enzymes. We investigated the influence of GEM treatment on the production of malondialdehyde (MDA) level in tissues of normolipidaemic Wistar and Fisher rats which is an index of lipid peroxidation. Because serum paraoxonase 1 (PON1) is an important enzyme with specific protective function on metabolism of lipid peroxides, we examined the influence of GEM on PON1 activity in liver and serum. MDA level and enzyme activities were also determined 10 days after withdrawal of GEM treatment. The significantly increased levels of MDA in liver, kidney and heart of both rat strains were obtained after 3 weeks of GEM treatment. We propose two possibilities for the increase of MDA levels caused by GEM, induction of peroxisome proliferation and activities of enzymes that participated in occurrence of H(2)O(2) and possible reduction of enzyme activities including in H(2)O(2) metabolism. Ten days after withdrawal of GEM treatment, MDA levels in all tissue levels of both rat strains were less in comparison with GEM treatment. GEM caused a significant drop of PON1 activity in serum and liver of Fisher rats, and in liver of Wistar rats. We suggest that GEM, through induction of lipid peroxidation, caused the damage of hepatocytes with consequent reduction of PON1 synthesis. The increase in PON1 activity in serum and tissues of both rat strains 10 days after withdrawal of GEM treatment shows the fast recovery of enzyme synthesis. |
| | |
Authors:
|
Marija Macan; Macan Marija; Paško Konjevoda; Konjevoda Paško; Jasna Lovric; Lovrić Jasna; Marijan Koprivanac; Koprivanac Marijan; Marta Kelava; Kelava Marta; Nada Vrkic; Vrkić Nada; Vlasta Bradamante; Bradamante Vlasta |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-02-24 |
Journal Detail:
|
Title: Basic & clinical pharmacology & toxicology Volume: 108 ISSN: 1742-7843 ISO Abbreviation: Basic Clin. Pharmacol. Toxicol. Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-05-13 Completed Date: 2012-01-09 Revised Date: 2012-01-13 |
Medline Journal Info:
|
Nlm Unique ID: 101208422 Medline TA: Basic Clin Pharmacol Toxicol Country: Denmark |
Other Details:
|
Languages: eng Pagination: 428-35 Citation Subset: IM |
Copyright Information:
|
© 2011 The Authors. Basic & Clinical Pharmacology & Toxicology © 2011 Nordic Pharmacological Society. |
Affiliation:
|
Department of Pharmacology, School of Medicine, University of Zagreb, Croatia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aryldialkylphosphatase / blood, metabolism* Gemfibrozil / metabolism, pharmacology*, toxicity Heart / drug effects, physiology Hydrogen Peroxide / metabolism Hypolipidemic Agents / metabolism, pharmacology*, toxicity Kidney / drug effects, enzymology Lipid Peroxidation / drug effects Lipid Peroxides / metabolism Liver / drug effects, enzymology, metabolism Male Malondialdehyde / metabolism* Peroxisomes / drug effects Rats Rats, Inbred F344 Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
0/Hypolipidemic Agents; 0/Lipid Peroxides; 25812-30-0/Gemfibrozil; 542-78-9/Malondialdehyde; 7722-84-1/Hydrogen Peroxide; EC 3.1.8.1/Aryldialkylphosphatase |
| Comments/Corrections | |
Erratum In:
|
Basic Clin Pharmacol Toxicol. 2011 Oct;109(4):319 Note: Marija, Macan [corrected to Macan, Marija]; Paško, Konjevoda [corrected to Konjevoda, Paško]; Jasna, Lovrić [corrected to Lovric, Jasna];Marijan, Koprivanac [corrected to Koprivanac, Marijan]; Marta, Kelava [corrected to Kelava, Marta]; Nada, Vrkić [corrected to Vrkic, Nada]; Vlasta, Bradamante [corrected to Bradamante, Vlasta] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Protective Effect of Aminophylline against Cigarette Smoke Extract- Induced Apoptosis in Human Lung ...
Next Document: MONOCYTE-SUPPRESSING EFFECT OF BEZAFIBRATE BUT NOT OMEGA-3 FATTY ACIDS IN PATIENTS WITH ISOLATED HYP...