Document Detail


Influence of fructose concentration on myocardial infarction in senile diabetic and non-diabetic patients.
MedLine Citation:
PMID:  19924606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Fructose intake has been increased steadily during the past two decades. Fructose, like other reducing sugars can react with proteins, which may account for aging and myocardial infarction. Fructose participates in glycation (fructation) and AGE formation some 10 times faster than glucose. This study aims to determine the fructose concentration and correlate with antioxidant status in senile diabetic and non-diabetic patients with myocardial infarction.
METHODS: The study included one hundred twenty six subjects. Out of them 31 were normal senile subjects, 33 were senile diabetic patients without myocardial infarction, 32 were senile diabetic patients with myocardial infarction and 30 were senile non-diabetic patients with myocardial infarction. The patients were selected on clinical grounds from National Institute of Cardiovascular Diseases, Karachi and Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
RESULTS: Serum fructose was significantly increased in senile diabetic patients with and without myocardial infarction and senile non-diabetic patients with myocardial infarction as compared with senile control subjects. Serum total antioxidant status was found to be significantly decreased in senile diabetic patients with and without myocardial infarction and senile non-diabetic patients with myocardial infarction as compared with senile control subjects. Fasting blood glucose, HbA (1C) and serum fructosamine were significantly increased in senile diabetic patients with or without myocardial infarction as compared with senile non-diabetic patients with myocardial infarction and senile control subjects. Negative significant correlation was observed between serum fructose and serum total antioxidant status in diabetic and non-diabetic patients with myocardial infarction. Positive significant correlation was observed between serum fructose and s-AGEs in diabetic and non-diabetic patients with myocardial infarction.
CONCLUSIONS: This study revealed that increased fructose concentration and decreased antioxidant status might have a role in the myocardial infarction.
Authors:
A Gul; M A Rahman; S N Hasnain
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-18
Journal Detail:
Title:  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association     Volume:  117     ISSN:  1439-3646     ISO Abbreviation:  Exp. Clin. Endocrinol. Diabetes     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-01-26     Revised Date:  2011-03-15    
Medline Journal Info:
Nlm Unique ID:  9505926     Medline TA:  Exp Clin Endocrinol Diabetes     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  605-9     Citation Subset:  IM    
Copyright Information:
Copyright J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart . New York.
Affiliation:
Department of Biochemistry, Ziauddin University, Shahrah-e- Ghalib, Clifton, Karachi, Pakistan. anjummurtaza@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging / metabolism
Alzheimer Disease / blood*,  complications
Analysis of Variance
Antioxidants / metabolism
Blood Glucose / metabolism
Diabetes Mellitus, Type 2 / blood*,  complications
Female
Fructosamine / blood
Fructose / blood*
Humans
Male
Middle Aged
Myocardial Infarction / blood*,  complications
Oxidative Stress
Patient Selection
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Blood Glucose; 30237-26-4/Fructose; 4429-04-3/Fructosamine
Comments/Corrections
Comment In:
Exp Clin Endocrinol Diabetes. 2011 Feb;119(2):129   [PMID:  20625971 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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