| Influence of Exercise on Airway Epithelia in Cystic Fibrosis: A review. | |
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MedLine Citation:
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PMID: 22297805 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT: Regular exercise is recommended as part of cystic fibrosis (CF) physiotherapy. Exercise delays the development of pulmonary disease in CF patients; however, the cellular mechanisms responsible for these improvements are unclear. This review expands upon the hypothesis that exercise improves CF pathophysiological ion dysregulation via purinergic and adrenergic pathways by describing the effects of AMP-activated protein kinase, atrial natriuretic peptide, and arginine-vasopressin on CF airway epithelia. Activation of AMPK decreases Na absorption, increases airway surface liquid, and reduces oxidative stress and inflammation. Plasma atrial natriuretic peptide (ANP) inhibits the basolateral Na-K-ATPase, and thereby may reduce epithelial water absorption. Airway epithelia respond to plasma arginine-vasopressin (AVP) and secrete AVP in response to elevated bradykinin. AVP stimulates the basolateral Na/K/2Cl exchanger, thereby increasing Cl secretion, reducing Na, absorption, and promoting basolateral to luminal water flux. In addition, AVP may increase cilia beat frequency in airway epithelia via a Ca depend mechanism. This review will describe the effects of exercise on AMPK activation, ANP release, and AVP secretion; we hypothesize that the mechanical and metabolic perturbations that occur with exercise may be beneficial in preventing CF lung pathogenesis by improving airway hydration, mucociliary clearance, and reducing markers of inflammation. |
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Authors:
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Jason M Cholewa; Vincent J Paolone |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-31 |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: - ISSN: 1530-0315 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Springfield College, Springfield, MA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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