Document Detail

Influence of endogenous reproductive hormones on F2-isoprostane levels in premenopausal women: the BioCycle Study.
MedLine Citation:
PMID:  20679069     Owner:  NLM     Status:  MEDLINE    
Endogenous reproductive hormones and oxidative stress have been independently linked to risk of chronic disease but mostly in postmenopausal women. The interplay between endogenous reproductive hormones and oxidative stress among premenopausal women, however, has yet to be clearly elucidated. The objective of this study was to investigate the association between endogenous reproductive hormones and F(2)-isoprostanes in the BioCycle Study. Women aged 18-44 years from western New York State were followed prospectively for up to 2 menstrual cycles (n = 259) during 2005-2007. Estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin, F(2)-isoprostanes, and thiobarbituric acid-reactive substances were measured up to 8 times per cycle at clinic visits timed by using fertility monitors. F(2)-Isoprostane levels had an independent positive association with estradiol (beta = 0.02, 95% confidence interval: 0.01, 0.03) and inverse associations with sex hormone-binding globulin and follicle-stimulating hormone (beta = -0.04, 95% confidence interval: -0.07, -0.003; beta = -0.02, 95% confidence interval: -0.03, -0.002, respectively) after adjustment for age, race, age at menarche, gamma-tocopherol, beta-carotene, total cholesterol, and homocysteine by inverse probability weighting. Thiobarbituric acid-reactive substances, a less specific marker of oxidative stress, had similar associations. If F(2)-isoprostanes are specific markers of oxidative stress, these results call into question the commonly held hypothesis that endogenous estradiol reduces oxidative stress.
Enrique F Schisterman; Audrey J Gaskins; Sunni L Mumford; Richard W Browne; Edwina Yeung; Maurizio Trevisan; Mary Hediger; Cuilin Zhang; Neil J Perkins; Kathleen Hovey; Jean Wactawski-Wende;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2010-08-01
Journal Detail:
Title:  American journal of epidemiology     Volume:  172     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-11     Completed Date:  2010-09-28     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  430-9     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood,  urine
F2-Isoprostanes / blood*
Fertility / physiology*
Gonadal Steroid Hormones / blood,  urine
Menstrual Cycle / physiology*
Oxidative Stress
Premenopause / blood*
Prospective Studies
Young Adult
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/F2-Isoprostanes; 0/Gonadal Steroid Hormones

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