| Influence of dissolved oxygen concentration on the pharmacokinetics of alcohol in humans. | |
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MedLine Citation:
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PMID: 20201925 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Ethanol oxidation by the microsomal ethanol oxidizing system requires oxygen for alcohol metabolism, and a higher oxygen uptake increases the rate of ethanol oxidation. We investigated the effect of dissolved oxygen on the pharmacokinetics of alcohol in healthy humans (n = 49). The concentrations of dissolved oxygen were 8, 20, and 25 ppm in alcoholic drinks of 240 and 360 ml (19.5% v/v). METHODS: Blood alcohol concentrations (BACs) were determined by converting breath alcohol concentrations. Breath samples were collected every 30 min when the BAC was higher than 0.015%, 20 min at BAC < or =0.015%, 10 min at BAC < or =0.010%, and 5 min at BAC < or =0.006%. RESULTS: The high dissolved oxygen groups (20, 25 ppm) descended to 0.000% and 0.050% BAC faster than the normal dissolved oxygen groups (8 ppm; p < 0.05). In analyzing pharmacokinetic parameters, AUC(inf) and K(el) of the high oxygen groups were lower than in the normal oxygen group, while C(max) and T(max) were not significantly affected. In a Monte Carlo simulation, the lognormal distribution of mean values of AUC(inf) and t(1/2) was expected to be reduced in the high oxygen group compared to the normal oxygen group. CONCLUSIONS: In conclusion, elevated dissolved oxygen concentrations in alcoholic drinks accelerate the metabolism and elimination of alcohol. Thus, enhanced dissolved oxygen concentrations in alcohol may have a role to play in reducing alcohol-related side effects and accidents. |
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Authors:
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In-hwan Baek; Byung-yo Lee; Kwang-il Kwon |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-03-01 |
Journal Detail:
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Title: Alcoholism, clinical and experimental research Volume: 34 ISSN: 1530-0277 ISO Abbreviation: Alcohol. Clin. Exp. Res. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7707242 Medline TA: Alcohol Clin Exp Res Country: England |
Other Details:
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Languages: eng Pagination: 834-9 Citation Subset: IM |
Affiliation:
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Chungnam National University, Daejeon, South Korea. |
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| Comments/Corrections | |
Comment In:
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Alcohol Clin Exp Res. 2010 Oct;34(10):1671-2; author reply 1673-4
[PMID:
20608907
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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