Document Detail

Influence of diet, exercise, and serum vitamin d on sarcopenia in postmenopausal women.
MedLine Citation:
PMID:  23190588     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The objective of this study is to investigate the effects of 12 months of dietary weight loss and/or aerobic exercise on lean mass and the measurements defining sarcopenia in postmenopausal women and to examine the potential moderating effect of serum 25-hydroxyvitamin D (25(OH)D) and age.
METHODS: Four hundred thirty-nine overweight and obese postmenopausal women were randomized to diet modification (N = 118), exercise (N = 117), diet + exercise (N = 117), or control (N = 87). The diet intervention was a group-based program with a 10% weight loss goal. The exercise intervention was 45 min·d, 5 d·wk, of moderate-to-vigorous intensity aerobic activity. Total and appendicular lean mass (ALM) were quantified by dual x-ray absorptiometry at baseline and 12 months. A skeletal muscle index (SMI = ALM (kg) / height (m)) and the prevalence of sarcopenia (SMI <5.67 kg·m) were calculated. Serum 25(OH)D was assayed using a competitive chemiluminescent immunoassay.
RESULTS: Dietary weight loss resulted in a significant decrease in lean mass and a borderline significant decrease in ALM and SMI compared with controls. In contrast, aerobic exercise significantly preserved ALM and SMI. Diet + exercise attenuated the loss of ALM and SMI compared with diet alone and did not result in significant loss of total mass or ALM compared with controls. Neither serum 25(OH)D nor age was significant moderators of the intervention effects.
CONCLUSIONS: Aerobic exercise added to dietary weight loss can attenuate the loss of ALM during weight loss and may be effective for the prevention and treatment of sarcopenia among overweight and obese postmenopausal women.
Caitlin Mason; Liren Xiao; Ikuyo Imayama; Catherine R Duggan; Karen E Foster-Schubert; Angela Kong; Kristin L Campbell; Ching-Yun Wang; Adriana Villasenor; Marian L Neuhouser; Catherine M Alfano; George L Blackburn; Anne McTiernan
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  45     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-20     Completed Date:  2013-11-14     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  607-14     Citation Subset:  IM; S    
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MeSH Terms
Confidence Intervals
Middle Aged
Obesity / diet therapy,  therapy*
Outcome Assessment (Health Care)
Sarcopenia / prevention & control,  therapy*
Vitamin D / blood*
Grant Support
2R25CA057699-16/CA/NCI NIH HHS; 5KL2RR025015-03/RR/NCRR NIH HHS; KL2 TR000421/TR/NCATS NIH HHS; R01 CA102504/CA/NCI NIH HHS; R01 CA105204/CA/NCI NIH HHS; R25 CA057699/CA/NCI NIH HHS; R25 CA094880/CA/NCI NIH HHS; R25 CA094880/CA/NCI NIH HHS; U54 CA116847/CA/NCI NIH HHS; U54-CA116847/CA/NCI NIH HHS; UL1 TR000423/TR/NCATS NIH HHS; //Canadian Institutes of Health Research
Reg. No./Substance:
1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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