Document Detail


The influence of device position on the flow within the Penn State 12 cc pediatric ventricular assist device.
MedLine Citation:
PMID:  22929894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ventricular assist devices are a commonly used heart failure therapy for adult patients as bridge-to-transplant or bridge-to-recovery tools. The application of adult ventricular assist devices in pediatric patients has led to increased thrombotic events. Therefore, we have been developing a pediatric ventricular assist device (PVAD), the Penn State 12 cc PVAD. It is designed for patients with a body weight of 5-15 kg and has a stroke volume of 12 cc. Clot formation is the major concern. It is correlated to the coagulability of blood, the blood contacting materials and the fluid dynamics within the system. The intent is for the PVAD to be a long term therapy. Therefore, the system may be oriented in different positions according to the patient's behavior. This study evaluates for the first time the impact of position on the flow patterns within the Penn State 12 cc PVAD, which may help to improve the PVAD design concerning chamber and ports geometries. The fluid dynamics are visualized by particle image velocimetry. The evaluation is based on inlet jet behavior and calculated wall shear rates. Vertical and horizontal model orientations are compared, both with a beat rate of 75, outlet pressures of 90/60 mm Hg and a flow rate of 1.3 l/min. The results show a significant change of the inlet jet behavior and the development of a rotational flow pattern. Vertically, the inlet jet is strong along the wall. It initiates a rotational flow pattern with a wandering axis of rotation. In contrast, the horizontal model orientation results show a weaker inlet jet along the wall with a nearly constant center of rotation location, which can be correlated to a higher risk of thrombotic events. In addition, high speed videography illustrates differences in the diaphragm motion during diastole. Diaphragm opening trajectories measurements determine no significant impact of the density of the blood analog fluids. Hence, the results correlate to human blood.
Authors:
Markus Schönberger; Steven Deutsch; Keefe B Manning
Related Documents :
23807174 - A study of the transport and immobilisation mechanisms of human red blood cells in a pa...
18386764 - Pulsating tumour in the clavicular region of a chronic haemodialysis patient with ipsil...
19729904 - Etanercept clearance during an in vitro model of continuous venovenous hemofiltration.
1519174 - Correction of steal syndrome secondary to hemodialysis access fistulas: a simplified qu...
6934544 - Cord-blood tyrosine levels in the full-term phenylketonuric fetus and the "justificatio...
23837874 - Detection of muramyl dipeptide-sensing pathway defects in monocytes of patients with cr...
Publication Detail:
Type:  Evaluation Studies; In Vitro; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  58     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:    2012 Sep-Oct
Date Detail:
Created Date:  2012-08-30     Completed Date:  2013-01-25     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  481-93     Citation Subset:  IM    
Affiliation:
Department of Bioengineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Flow Velocity
Child
Computer-Aided Design
Heart-Assist Devices* / statistics & numerical data
Hemodynamics
Humans
Hydrodynamics
Models, Cardiovascular
Pennsylvania
Prosthesis Design
Pulsatile Flow
Systole
Universities
Grant Support
ID/Acronym/Agency:
HV48191/HV/NHLBI NIH HHS; N01 HV048191/HV/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Identifying hemodialysis catheter recirculation using effective ionic dialysance.
Next Document:  Long-term tolerance of airway silicone stent in patients with post-tuberculosis tracheobronchial ste...