| Influence of Dai-kenchu-to (DKT) on human portal blood flow. | |
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MedLine Citation:
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PMID: 18613410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Dai-kenchu-to (DKT) is known as an herbal medicine used for postoperative ileus. However, no report exists about the effect of DKT on portal blood flow. The aim of this study is to clarify the influence of DKT on portal blood flow. METHODOLOGY: To healthy volunteers (Healthy; n = 6), cirrhotic patients (Cirrhosis; n = 7) and liver-transplant patients (LTx; n = 3), DKT (2.5g) with 100mL of warm water was orally administrated in the DKT group, and only warm water was administrated in the control group. The portal blood flow rate (M-VEL: cm/sec.) and portal blood flow (Flow volume: mL/min.) was measured each time after administration using an ultrasonic Doppler method. Furthermore, the arterial blood pressure and heart rate was measured at the same time points. RESULTS: In the DKT group, a significant increase of M-VEL (120%) and flow volume (150%) 30 minutes after administration was observed in both Healthy and Cirrhosis in comparison with the control group. In LTx, there was also a significant increase of flow volume (128%) 30 minutes after administration. However, there was no change in average blood pressure and heart rate in all groups. CONCLUSIONS: DKT increases portal blood flow in early phase after oral administration without any significant changes in the blood pressure and heart rate. |
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Authors:
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Takashi Ogasawara; Yuji Morine; Tetsuya Ikemoto; Satoru Imura; Masahiko Fujii; Yuji Soejima; Mitsuo Shimada |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 55 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2008 Mar-Apr |
Date Detail:
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Created Date: 2008-07-10 Completed Date: 2008-12-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
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Languages: eng Pagination: 574-7 Citation Subset: IM |
Affiliation:
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Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Plant Extracts / pharmacology* Portal Vein / drug effects*, physiology* Regional Blood Flow / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts; 0/dai-kenchu-to |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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