Document Detail


Influence of DRD2 and ANKK1 polymorphisms on the manifestation of withdrawal syndrome symptoms in alcohol addiction.
MedLine Citation:
PMID:  23238469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: We investigated the relationship between withdrawal syndrome symptoms and dopamine receptor 2 DRD2 gene polymorphisms-141 C I/D (rs1799732) exon 8 G/A (rs6276) and ANKK1 (Ankyrin Repeat and Kinase Domain Containing 1) gene polymorphism Taq1A (rs1800497).
MATERIAL: A total number of 213 patients who met the ICD 10 criteria for given phenotypes were enrolled in the study. Those phenotypes included: dissocial personality disorder, early onset, alcohol withdrawal syndrome with seizures, alcohol withdrawal syndrome with delirium tremens, and alcohol withdrawal syndrome with seizures and delirium tremens.
RESULTS: Our results show statistically significant associations between SNP in exon 8 A/G in the DRD2 gene and alcohol withdrawal syndrome with seizures, and between SNP in promoter -141 C I/D in the DRD2 gene and early onset of alcohol dependence (AD). The A/A genotype in exon 8 A/G polymorphism seems to be a positive predictive factor for the presence or the lack of seizures in alcohol withdrawal syndrome. The A/G genotype is possibly a protective factor for this AD phenotype.
CONCLUSIONS: These results suggest that both investigated DRD2 polymorphisms have an impact on the AD phenotype. The findings of the presented study reconfirm that dopamine receptor 2 gene polymorphisms are associated with alcohol addiction and alcohol withdrawal syndrome.
Authors:
Anna Grzywacz; Andrzej Jasiewicz; Iwona Małecka; Aleksandra Suchanecka; Elżbieta Grochans; Beata Karakiewicz; Agnieszka Samochowiec; Przemysław Bieńkowski; Jerzy Samochowiec
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacological reports : PR     Volume:  64     ISSN:  1734-1140     ISO Abbreviation:  Pharmacol Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-14     Completed Date:  2013-08-02     Revised Date:  2013-09-05    
Medline Journal Info:
Nlm Unique ID:  101234999     Medline TA:  Pharmacol Rep     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  1126-34     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Pomeranian Medical University, Broniewskiego 26, PL 71-460 Szczecin, Poland. annagrzywacz@gazeta.pl
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcoholism / genetics*
Female
Genotype
Humans
Male
Polymorphism, Single Nucleotide*
Protein-Serine-Threonine Kinases / genetics*
Receptors, Dopamine D2 / genetics*
Substance Withdrawal Syndrome / genetics*
Chemical
Reg. No./Substance:
0/DRD2 protein, human; 0/Receptors, Dopamine D2; EC 2.7.11.1/ANKK1 protein, human; EC 2.7.11.1/Protein-Serine-Threonine Kinases

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