Document Detail

Influence of correction of ocular magnification on spectral-domain OCT retinal nerve fiber layer measurement variability and performance.
MedLine Citation:
PMID:  24781941     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To analyze the influence of ocular magnification on the peripapillary retinal nerve fiber layer (RNFL) thickness measurement and its performance as acquired with spectral-domain optical coherence tomography (SD-OCT).
METHODS: Spectral domain OCT measurements from 108 normal eyes (59 subjects) and 72 glaucoma eyes (58 patients) were exported and custom software was used to correct RNFL measurements for ocular magnification. Retinal nerve fiber layer prediction limits in normal subjects, structure-function relationships, and RNFL performance for detection of glaucoma were compared before and after correction for ocular magnification (Bennett's formula). Association of disc area with cross-sectional RNFL area was explored.
RESULTS: The median (interquartile range, [IQR]) visual field mean deviation and scaling factor were 0 (-0.85 to 0.73) dB and 0.96 (0.93-1.00) in normal eyes and -4.0 (-6.0 to -2.2) dB and 0.99 (0.95-1.03) in the glaucoma group (P < 0.001 and P = 0.003, respectively; average correction 3%). Correction for ocular magnification caused a reversal of the negative relationship between the cross-sectional RNFL area and axial length (slope = -0.022 mm(2)/mm, P = 0.015 vs. = 0.22 mm(2)/mm, P = 0.007). However, such correction did not change RNFL prediction limits (except in superior and nasal quadrants), improve global or regional structure-function relationships, or enhance the ability of RNFL measurements to discriminate glaucoma from normal eyes (P > 0.05). The cross-sectional RNFL area was not correlated with optic disc area (P = 0.325).
CONCLUSIONS: Correction of RNFL measurements for ocular magnification did not improve prediction limits in normal subjects or enhance the performance of SD-OCT in this group of eyes in which the axial length did not deviate significantly from average values. The cross-sectional area of the RNFL was not related to the optic disc area.
Sara Nowroozizadeh; Nila Cirineo; Navid Amini; Shane Knipping; Ted Chang; Tom Chou; Joseph Caprioli; Kouros Nouri-Mahdavi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2014-04-29
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  55     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-06-06     Completed Date:  2014-07-29     Revised Date:  2014-08-19    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3439-46     Citation Subset:  IM    
Copyright Information:
Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
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MeSH Terms
Cross-Sectional Studies
Glaucoma / pathology*
Middle Aged
Predictive Value of Tests
Prospective Studies
ROC Curve
Reproducibility of Results
Retinal Ganglion Cells / pathology*
Tomography, Optical Coherence / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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