| Influence of a Controlled Environment Simulating an In-flight Airplane Cabin on Dry Eye Disease. | |
| | |
MedLine Citation:
|
PMID: 23412090 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: To evaluate symptoms, signs and the levels of 16 tears inflammatory mediators of dry eye (DE) patients exposed to an environment simulating an in-flight air cabin in an environmental chamber. Methods: Twenty DE patients were exposed to controlled environment simulating an in-flight airplane cabin [Simulated in-flight condition (SIC)] of 23ºC, 5% relative humidity, localized air flow, and 750 millibars (mb) of barometric pressure. As controls, 15 DE patients were subjected to a simulated standard condition (SSC) of 23ºC, 45% relative humidity, and 930 mb. A DE-symptoms questionnaire, diagnostic tests, and determination of 16 tear molecules by multiplex bead array were performed before and 2 hr after exposure. Results: After SIC exposure, DE patients became more symptomatic, suffered a significant (p≤0.05) decrease in tear stability (tear break-up time) (from 2.18±0.28 to 1.53±0.20), and tear production (Phenol red thread test), and a significant (p≤0.05) increase in corneal staining, both globally (0.50±0.14 before and 1.25 ± 0.19 after) and in each area (Baylor scale). After SSC, DE patients only showed a mild but significant (p≤0.05) increase in central and inferior corneal staining. Consistently, tear levels of IL-6 and MMP-9 significantly increased and tear EGF significantly decreased (p≤0.05) only after SIC. Conclusions: The controlled adverse environment conditions in this environmental chamber can simulate the conditions in which DE patients might be exposed during flight. As this clearly impaired their lacrimal functional unit, it would be advisable that DE patients use therapeutic strategies capable of ameliorating these adverse episodes. |
| | |
Authors:
|
Marisa Teson; Maria J Gonzalez-Garcia; Alberto Lopez-Miguel; Amalia Enriquez-de-Salamanca; Vicente Martin-Montanez; Maria Jesus Benito; Maria Eugenia Mateo; Michael E Stern; Margarita Calonge |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-2-14 |
Journal Detail:
|
Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-2-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
IOBA, University of Valladolid, Valladolid, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Targeted overexpression of TGF-? in the corneal epithelium of adult transgenic mice induces changes ...
Next Document: A nested case control study of plasma ICAM-1, E-selectin and TNF receptor 2 levels, and incident pri...