Document Detail


Influence of a controlled environment simulating an in-flight airplane cabin on dry eye disease.
MedLine Citation:
PMID:  23412090     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate symptoms, signs, and the levels of 16 tears inflammatory mediators of dry eye (DE) patients exposed to an environment simulating an in-flight air cabin in an environmental chamber.
METHODS: Twenty DE patients were exposed to controlled environment simulating an in-flight airplane cabin (simulated in-flight condition [SIC]) of 23°C, 5% relative humidity, localized air flow, and 750 millibars (mb) of barometric pressure. As controls, 15 DE patients were subjected to a simulated standard condition (SSC) of 23°C, 45% relative humidity, and 930 mb. A DE symptoms questionnaire, diagnostic tests, and determination of 16 tear molecules by multiplex bead array were performed before and 2 hours after exposure.
RESULTS: After SIC exposure, DE patients became more symptomatic, suffered a significant (P ≤ 0.05) decrease in tear stability (tear break up time) (from 2.18 ± 0.28 to 1.53 ± 0.20), and tear volume (phenol red thread test), and a significant (P ≤ 0.05) increase in corneal staining, both globally (0.50 ± 0.14 before and 1.25 ± 0.19 after) and in each area (Baylor scale). After SSC, DE patients only showed a mild, but significant (P ≤ 0.05), increase in central and inferior corneal staining. Consistently, tear levels of IL-6 and matrix metalloproteinase (MMP)-9 significantly increased and tear epidermal growth factor (EGF) significantly decreased (P ≤ 0.05) only after SIC.
CONCLUSIONS: The controlled adverse environment conditions in this environmental chamber can simulate the conditions in which DE patients might be exposed during flight. As this clearly impaired their lacrimal functional unit, it would be advisable that DE patients use therapeutic strategies capable of ameliorating these adverse episodes.
Authors:
Marisa Tesón; María J González-García; Alberto López-Miguel; Amalia Enríquez-de-Salamanca; Vicente Martín-Montañez; María Jesús Benito; María Eugenia Mateo; Michael E Stern; Margarita Calonge
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-03-01
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  54     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-28     Completed Date:  2013-05-14     Revised Date:  2013-08-08    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2093-9     Citation Subset:  IM    
Affiliation:
Institute for Applied OphthalmoBiology (IOBA), University of Valladolid, Valladolid, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aircraft*
Atmosphere Exposure Chambers
Cornea / pathology
Dry Eye Syndromes / etiology*,  metabolism,  pathology,  prevention & control
Environment, Controlled*
Environmental Exposure / adverse effects*
Female
Humans
Humidity
Male
Middle Aged
Tears / secretion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Targeted overexpression of TGF-? in the corneal epithelium of adult transgenic mice induces changes ...
Next Document:  A nested case control study of plasma ICAM-1, E-selectin and TNF receptor 2 levels, and incident pri...