Document Detail

Influence of cinnamaldehyde on viral myocarditis in mice.
MedLine Citation:
PMID:  20460981     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: This study was designed to examine the effects of cinnamaldehyde on coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC) and underlying signaling, with a focus on the toll-like receptor (TLR)4-nuclear factor (NF)-kappaB pathway. METHODS AND RESULTS: The antiviral and myocardial effects of cinnamaldehyde and its metabolite cinnamic acid were evaluated both in vitro and in vivo. Our results showed that cinnamic acid but not cinnamaldehyde reduced the viral titer in CVB3-infected myocardial cells. Our in vivo study demonstrated that intraperitoneal injection of either cinnamaldehyde or cinnamic acid significantly enhanced the survival rate and reduced myocardial viral titer in VMC mice compared with CVB3-infected controls (P < 0.05). There was no significant difference in effectiveness between the cinnamic acid and the cinnamaldehyde groups (P > 0.05). Cinnamaldehyde reduced plasma nitric oxide (NO) content, NF-kappaB, inducible nitric oxide synthase and TLR4 expression and decreased inflammatory cell infiltrate in myocardium from VMC mice 7 days after viral inoculation (P < 0.05). However, these effects were not observed with cinnamic acid treatment. Statistical significance was present between cinnamic acid and cinnamaldehyde in their effects on plasma NO content, NF-kappaB, inducible nitric oxide synthase and TLR4 expression (P < 0.05). CONCLUSION: Our data suggest that although cinnamaldehyde has antiviral effects on VMC through its metabolite, cinnamic acid, it directly reduces the inflammation in VMC by inhibiting the TLR4-NF-kappaB signal transduction pathway.
YuanYuan Ding; Lin Qiu; GangTao Zhao; Jingfeng Xu; Siwang Wang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  340     ISSN:  1538-2990     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-09     Completed Date:  2010-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  114-20     Citation Subset:  AIM; IM    
Institute of Materia Medica, Fourth Military Medical University, Xi'an, China.
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MeSH Terms
Acrolein / analogs & derivatives*,  therapeutic use
Antiviral Agents / therapeutic use*
Blotting, Western
Cinnamates / therapeutic use*
Coxsackievirus Infections / drug therapy*
Enterovirus B, Human / drug effects*
Heart / drug effects,  virology
Mice, Inbred BALB C
Myocarditis / drug therapy*,  virology
Myocardium / chemistry,  pathology
NF-kappa B / analysis
Nitric Oxide / blood
Nitric Oxide Synthase Type II / analysis
Toll-Like Receptor 4 / analysis
Tumor Necrosis Factor-alpha / analysis
Viral Load / drug effects
Reg. No./Substance:
0/Antiviral Agents; 0/Cinnamates; 0/NF-kappa B; 0/Tlr4 protein, mouse; 0/Toll-Like Receptor 4; 0/Tumor Necrosis Factor-alpha; 10102-43-9/Nitric Oxide; 104-55-2/cinnamic aldehyde; 107-02-8/Acrolein; 621-82-9/cinnamic acid; EC Oxide Synthase Type II

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