| Influence of CYP2C19 genotypes on graft pathological findings and postoperative liver function in recipients after living-donor liver transplantation. | |
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MedLine Citation:
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PMID: 21183874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: New graft cytochrome P450 2C19 (CYP2C19) should have different characteristics after living-donor liver transplantation (LDLT). We prospectively investigated the influence of genotypes of CYP2C19 in liver graft pathological finding (GPF) and postoperative liver function (POLF) of recipients after LDLT. MATERIAL/METHODS: Among 60 consecutive patients who underwent LDLT, 36 recipients developed sudden-onset abnormal liver function and required liver biopsy, while the remaining 24 recipients did not require biopsy. LDLT recipient blood samples were genotyped for CYP2C19 variants, and recipients were categorized as homozygous extensive metabolizers (HomEM), heterozygous extensive metabolizers (HetEM), and poor metabolizers (PM). RESULTS: The acute rejection rate was 15.0% (9/60). There were 4 characteristics of GPF when abnormal POLF occurred. Logistic regression analysis showed that the risk estimate of abnormal POLF was 26.7 times higher for LDLT recipients with the CYP2C19 HomEM genotype as compared to the PM genotype, and 5.0 times higher for LDLT recipients with the HomEM genotype as compared to the HetEM genotype. A linear trend relationship was found between the incidence of abnormal POLF and the CYP2C19 genotype. CONCLUSIONS: These results suggest that the speed of drug metabolism as characterized by the CYP2C19 genotype (HomEM > HetEM > PM) may affect the outcome after LDLT; thus, CYP2C19 genotyping may be valuable for predicting abnormal POLF with different GPF after LDLT. |
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Authors:
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King-Wah Chiu; Toshiaki Nakano; Tsung-Hui Hu; Hui-Peng Tseng; Yu-Fan Cheng; Bruno Jawan; Hock-Liew Eng; Shigeru Goto; Chao-Long Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of transplantation : quarterly of the Polish Transplantation Society Volume: 15 ISSN: 1425-9524 ISO Abbreviation: Ann. Transplant. Publication Date: 2010 Oct-Dec |
Date Detail:
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Created Date: 2010-12-24 Completed Date: 2011-04-19 Revised Date: 2012-05-09 |
Medline Journal Info:
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Nlm Unique ID: 9802544 Medline TA: Ann Transplant Country: Poland |
Other Details:
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Languages: eng Pagination: 38-43 Citation Subset: IM |
Affiliation:
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Liver Transplant Program, Chang Gung Memorial Hospital-Kaohsiung Medical Center and Chang Gung University College of Medicine, 123 Ta-Pei Road, Taiwan, Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aryl Hydrocarbon Hydroxylases / genetics* Female Graft Rejection / pathology* Humans Liver Function Tests Liver Transplantation / physiology* Living Donors* Male Middle Aged Postoperative Period Prospective Studies Risk Assessment Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/CYP2C19 protein, human |
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