Document Detail


Influence of the Angiotensin II type I receptor gene 1166A > C polymorphism on BP and aortic pulse wave velocity among Malays.
MedLine Citation:
PMID:  17227479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Angiotensin II type 1 receptor (AGT1R) gene 1166A > C polymorphism has been shown to be associated with essential hypertension and aortic stiffness as measured by carotid femoral pulse wave velocity (PWV). This study was carried out to investigate the association of the 1166A > C polymorphism with blood pressure (BP) and PWV among Malay hypertensive and normotensive subjects. Two hundred and one hypertensive subjects without evidence of cardiovascular (CV) complications and 201 age- and sex-matched normotensive subjects were studied in a cross-sectional design. Blood pressures (BP) and PWV were measured, and 1166A > C genotype was determined by polymerase chain reaction followed by restriction enzyme digestion. The 1166C allele frequency was 7.96% and 7.73% among Malay hypertensive and normotensive subjects, respectively. There was no association of the 1166A > C polymorphism with BP in the hypertensive, normotensive or overall Malay populations. PWV was significantly higher among 1166C allele carriers as compared to non-carriers (10.52 +/- 1.82 vs. 10.15 +/- 1.80, p = 0.040) in the overall population, but not in the hypertensive and normotensive populations separately. In conclusion, the frequency of 1166C polymorphism is similar among Malay hypertensive and normotensive subjects. This polymorphism has no association with BP but may have an influence on PWV in Malays, which needs further investigation.
Authors:
A Rehman; A H G Rasool; L Naing; T M Roshan; A R A Rahman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of human genetics     Volume:  71     ISSN:  0003-4800     ISO Abbreviation:  Ann. Hum. Genet.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-17     Completed Date:  2007-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0416661     Medline TA:  Ann Hum Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  86-95     Citation Subset:  IM    
Affiliation:
School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia. asia@kb.usm.my
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MeSH Terms
Descriptor/Qualifier:
Aged
Aorta / physiopathology*
Asian Continental Ancestry Group / genetics*
Female
Gene Frequency
Genotype
Humans
Hypertension / genetics
Malaysia
Male
Matched-Pair Analysis
Middle Aged
Polymorphism, Single Nucleotide*
Receptor, Angiotensin, Type 1 / genetics*
Chemical
Reg. No./Substance:
0/Receptor, Angiotensin, Type 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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