| Influence of acute alcohol ingestion on sympathetic neural responses to orthostatic stress in humans. | |
| | |
MedLine Citation:
|
PMID: 21325108 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Acute alcohol consumption is reported to decrease mean arterial pressure (MAP) during orthostatic challenge, a response that may contribute to alcohol-mediated syncope. Muscle sympathetic nerve activity (MSNA) increases during orthostatic stress to help maintain MAP, yet the effects of alcohol on MSNA responses during orthostatic stress have not been determined. We hypothesized that alcohol ingestion would blunt arterial blood pressure and MSNA responses to lower body negative pressure (LBNP). MAP, MSNA, and heart rate (HR) were recorded during progressive LBNP (-5, -10, -15, -20, -30, and -40 mmHg; 3 min/stage) in 30 subjects (age 24 ± 1 yr). After an initial progressive LBNP (pretreatment), subjects consumed either alcohol (0.8 g ethanol/kg body mass; n = 15) or placebo (n = 15), and progressive LBNP was repeated (posttreatment). Alcohol increased resting HR (59 ± 2 to 65 ± 2 beats/min, P < 0.05), MSNA (13 ± 3 to 19 ± 4 bursts/min, P < 0.05), and MSNA burst latency (1,313 ± 16 to 1,350 ± 17 ms, P < 0.05) compared with placebo (group × treatment interactions, P < 0.05). During progressive LBNP, a pronounced decrease in MAP was observed after alcohol but not placebo (group × time × treatment, P < 0.05). In contrast, MSNA and HR increased during all LBNP protocols, but there were no differences between trials or groups. However, alcohol altered MSNA burst latency response to progressive LBNP. In conclusion, the lack of MSNA adjustment to a larger drop in arterial blood pressure during progressive LBNP, coupled with altered sympathetic burst latency responses, suggests that alcohol blunts MSNA responses to orthostatic stress. |
| | |
Authors:
|
Jason R Carter; Sarah F Stream; John J Durocher; Robert A Larson |
Related Documents
:
|
17169588 - Biomechanical effects of glenoid retroversion in total shoulder arthroplasty. 21697438 - Learning to breathe and sing: development of respiratory-vocal coordination in young so... 3214258 - Ground reaction forces, center of pressure, and duration of stance with and without an ... 2794268 - Pericardiocentesis guided by a pulse generator. 20532698 - Drug mechanisms to help in managing resistant hypertension in obesity. 11509518 - Effects of bright light and melatonin on sleep propensity, temperature, and cardiac act... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2011-02-15 |
Journal Detail:
|
Title: American journal of physiology. Endocrinology and metabolism Volume: 300 ISSN: 1522-1555 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-04-27 Completed Date: 2011-06-28 Revised Date: 2012-09-19 |
Medline Journal Info:
|
Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
|
Languages: eng Pagination: E771-8 Citation Subset: IM |
Affiliation:
|
Dept. of Exercise Science, Michigan Technological University, 1400 Townsend Dr., Houghton, MI 49931, USA. jcarter@mtu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Pressure
/
drug effects Central Nervous System Depressants / blood, pharmacology* Ethanol / blood, pharmacology* Female Hemodynamics / drug effects Humans Hypotension, Orthostatic / physiopathology* Lower Body Negative Pressure Male Muscle, Skeletal / drug effects, innervation Regional Blood Flow / drug effects Sympathetic Nervous System / drug effects* Vascular Resistance / drug effects Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
HL-098676/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Central Nervous System Depressants; 64-17-5/Ethanol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys.
Next Document: Cost-utility of aspirin and proton pump inhibitors for primary prevention.