| Influence of AIN-93 diet on mortality and cardiac remodeling after myocardial infarction in rats. | |
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MedLine Citation:
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PMID: 21095625 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: The AIN-93 diet was proposed by the American Institute of Nutrition with the objective of standardising studies in experimental nutrition. Our objective was to analyze the effects of AIN-93 diet after myocardial infarction in rats. METHODS: Post weaning, the animals were divided into two groups: control (C, n=62), fed the standard diet of our laboratory (Labina); AIN-93 Group (n=70), fed the AIN-93 diet. Achieving 250g, the animals were subjected to myocardial infarction. RESULTS: Early mortality was increased in AIN-93 animals, associated with lower serum levels of calcium, magnesium, potassium, sodium, and phosphorus. On the other hand, after 90days, AIN-93 showed smaller normalized left ventricular dimensions. The caloric and carbohydrate intake was smaller, but the fat intake was higher in AIN-93 rats. AIN-93 group also showed increased levels of β-hydroxyacylcoenzyme A dehydrogenase and citrate synthase. In addition, serum levels of insulin and cardiac levels of malondialdehyde, metalloproteinases-2 and -9, and TNF-α and IFN-γ were decreased in the AIN-93 group. CONCLUSION: AIN-93 diet increased early mortality, while attenuated the chronic remodeling process after experimental coronary occlusion. Therefore, this diet has biological effects and should be use with attention in this model. |
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Authors:
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Lidiane P Ardisson; Marcos F Minicucci; Paula S Azevedo; Fernanda Chiuso-Minicucci; Beatriz B Matsubara; Luiz S Matsubara; Priscila P Santos; Heloisa B Assalin; Rosangela Novo; Ethel L Novelli; Léa Silvia Sant'ana; Sergio A R Paiva; Leonardo A M Zornoff |
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Publication Detail:
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Type: Journal Article Date: 2010-11-23 |
Journal Detail:
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Title: International journal of cardiology Volume: 156 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 265-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Internal Medicine Department, Botucatu Medical School, UNESP-São Paulo State University, Botucatu, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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