| The Influence of AIDS on the Morphometric and Immune Status of the Uterine Cervix of Autopsied Patients. | |
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MedLine Citation:
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PMID: 22211654 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Previous studies have shown that HIV infection is related to changes in the immune status of the mucosal surfaces. Such changes may also occur in the genital tract, since patients infected by HIV have the virus in their cervical secretions. Methods: Fragments of the uterine cervix of 29 autopsied women were collected at a university hospital from 1985 to 2008, and were divided in groups with and without AIDS. Image J software was used to measure the cervical epithelium and to count the epithelial cellular layers. Langerhans cells (LCs) and IgG positive cells were respectively immunostained with anti-S100 and anti-IgG. Results: Women with AIDS, when compared with women without AIDS, had thinner cervical epithelium (103.32 vs 116.71 m), lower number of cellular layers (10.41 vs 13.66 m), lower mean cell diameter (10.09 vs 11.51 m), less number of total LCs (11.19 vs 23.08 LCs/mm ), and higher percentage of IgG positive cells (22.64% vs 16.06%). All these results were significant. Conclusion: AIDS causes alterations in the structure of the cervical epithelium and in its extracellular matrix, leading to alterations in the local and systemic immunity, and triggering signs and opportunistic infections in the uterine cervix in the course of the disease. |
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Authors:
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Camila Lourencini Cavellani; Laura Penna Rocha; Simone Crystina da Silva Rosa; Lívia Ferreira Oliveira; Humberto Aparecido Faria; Janaínna Grazielle Pacheco Olegário; Rosana Rosa Miranda Corrêa; Vicente de Paula Antunes Teixeira |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-30 |
Journal Detail:
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Title: Current HIV research Volume: - ISSN: 1873-4251 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101156990 Medline TA: Curr HIV Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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The Disciplina de Patologia Geral Universidade Federal do Triângulo Mineiro Rua Frei Paulino, 30, CEP 38025-180, Uberaba-Minas Gerais Brasil. rosana@patge.uftm.edu.br. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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