| The Influence of the ABO Blood Type on the Distribution of von Willebrand Factor in Healthy Children With no Bleeding Symptoms. | |
| | |
MedLine Citation:
|
PMID: 21949039 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The purpose of this study was to determine the effect of ABO blood groups on von Willebrand factor-ristocetin cofactor activity (vWF-RCo) and on vWF-antigen (vWF-Ag) in children who have no personal or familial history of bleeding. Material and methods: A survey and testing were performed on 200 children with no personal or familial history of bleeding. In all, 100 of them belonged to blood group O, and the remaining 100 belonged to other blood groups. The blood samples were stored at -80°C for a maximum period of 2 weeks to detect vWF-RCo and vWF-Ag levels. Results: The mean vWF-Ag (±2 standard deviation [SD]) level in children with blood group O was 86% (±20%); and for those with non-O blood group, it was 98.8% (±25%). There was a significant difference between the 2 groups (P < .001). The mean vWF-RCo (±2 SD) level in children with blood group O was 89% (±23%); and for those with non-O blood group, it was 103% (±17%). There was a significant difference between those in the 2 groups (P < .001). The lowest value of vWF-Ag and vWF-RCo levels in children with blood group O was found to be 50%. In conclusion, we showed that the selection of normal ranges based on the ABO group might influence the clinical diagnosis of vWD and that while the approach of using ABO group ranges for a vWF-Ag level lower than 50 IU/dL is scientifically sound, it might not be useful to assist a clinician in identifying people at increased risk of bleeding. |
| | |
Authors:
|
Mehmet Akin; Can Balkan; Deniz Yilmaz Karapinar; Kaan Kavakli |
Related Documents
:
|
19822749 - Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lympha... 15961719 - Long-term and sustained comp-ang1 induces long-lasting vascular enlargement and enhance... 2250109 - The measurement of skin lymph flow by isotope clearance--reliability, reproducibility, ... 17541029 - Vascular remodeling: hemodynamic and biochemical mechanisms underlying glagov's phenome... 9376169 - Enzyme-histochemical demonstration of the intramural lymphatic network in the monkey je... 4062499 - Three-dimensional organization of lymphatics and their relationship to blood vessels in... 11146479 - Comparison of diffusion, blood oxygenation, and blood volume changes during global isch... 7810049 - Effect of the method of stunning and the interval between stunning and neck cutting on ... 20578099 - Cardiac shunt calculations made easy: a case-based approach. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-23 |
Journal Detail:
|
Title: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis Volume: - ISSN: 1938-2723 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9508125 Medline TA: Clin Appl Thromb Hemost Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Pediatric Hematology, Ege University, Bornova, Izmir, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Biomarkers of Inflammation, Growth Factor, and Coagulation Activation in Patients With Sickle Cell D...
Next Document: Diagnosis and Management of Isolated Subsegmental Pulmonary Embolism: Review and Assessment of the O...