Document Detail


Influence of 1-methyl-3-keto-4-phenylquinuclidinium bromide on rat tissue monoamine levels in vivo.
MedLine Citation:
PMID:  1036696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of 1-methyl-3-keto-4-phenylquinuclidinium bromide (MA540) on tissue monoamine levels in male rats have been compared to those of guanethidine. Neither compound influenced norepinephrine (NE) or 5-hydroxytryptamine (5-HT) levels in brain or epinephrine (E) levels in adrenal medulla. MA540 is about twice as potent as guanethidine as a heart NE depleting agent at both 8 and 24 h after drug administration. The durations of action of the compounds are similar. Unlike guanethidine, MA540 does not deplete NE in small intestine, which suggests that the drug may not elicit guanethidine-like intestinal side effects.
Authors:
J Leeling; J Bare; B Phillips; P Medon
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  26     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1976  
Date Detail:
Created Date:  1977-01-29     Completed Date:  1977-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1665-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Medulla / analysis
Animals
Biogenic Amines / analysis*
Brain Chemistry / drug effects
Epinephrine / analysis
Guanethidine / pharmacology
Intestine, Small / analysis
Male
Myocardium / analysis
Norepinephrine / analysis
Quinuclidines / pharmacology*
Rats
Serotonin / analysis
Chemical
Reg. No./Substance:
0/Biogenic Amines; 0/Quinuclidines; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 55-65-2/Guanethidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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