| Infliximab treatment of sarcoidosis. | |
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MedLine Citation:
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PMID: 12659618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether there is sufficient evidence in the literature to support the use of infliximab in the treatment of sarcoidosis. DATA SOURCES AND SELECTION: Literature was accessed through MEDLINE (1966-August 2002), OVID (2001-January 2003), and bibliographic searches. Additional databases were also searched. Published literature relevant to the use of infliximab in the treatment of sarcoidosis was evaluated. DATA SYNTHESIS: In theory, tumor-necrosis factor-alpha blockade appears to be an optimal strategy for treating sarcoidosis. Case series reporting the use of infliximab in refractory sarcoidosis was reviewed to evaluate its potential role as a treatment option. CONCLUSIONS: Although there is insufficient evidence suggesting that infliximab is an appropriate alternative to conventional treatment options as first-line therapy for sarcoidosis, the preliminary outlook on its use in treatment-refractory cases is promising. |
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Authors:
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Ryan N Serio |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 37 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-03-27 Completed Date: 2003-07-01 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: United States |
Other Details:
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Languages: eng Pagination: 577-81 Citation Subset: IM |
Affiliation:
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St. John's University, 164-40 95 St., Howard Beach, NY 11414-3704, USA. condram@msn.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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adverse effects,
pharmacology,
therapeutic use* Humans Sarcoidosis / drug therapy*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/infliximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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