Document Detail

Infliximab treatment of sarcoidosis.
MedLine Citation:
PMID:  12659618     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether there is sufficient evidence in the literature to support the use of infliximab in the treatment of sarcoidosis. DATA SOURCES AND SELECTION: Literature was accessed through MEDLINE (1966-August 2002), OVID (2001-January 2003), and bibliographic searches. Additional databases were also searched. Published literature relevant to the use of infliximab in the treatment of sarcoidosis was evaluated. DATA SYNTHESIS: In theory, tumor-necrosis factor-alpha blockade appears to be an optimal strategy for treating sarcoidosis. Case series reporting the use of infliximab in refractory sarcoidosis was reviewed to evaluate its potential role as a treatment option. CONCLUSIONS: Although there is insufficient evidence suggesting that infliximab is an appropriate alternative to conventional treatment options as first-line therapy for sarcoidosis, the preliminary outlook on its use in treatment-refractory cases is promising.
Ryan N Serio
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  37     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-27     Completed Date:  2003-07-01     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  577-81     Citation Subset:  IM    
St. John's University, 164-40 95 St., Howard Beach, NY 11414-3704, USA.
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MeSH Terms
Antibodies, Monoclonal / adverse effects,  pharmacology,  therapeutic use*
Sarcoidosis / drug therapy*,  physiopathology
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/infliximab

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