Document Detail

Infliximab for the treatment of disseminated pyoderma gangrenosum associated with ulcerative colitis. Case report and literature review.
MedLine Citation:
PMID:  17823524     Owner:  NLM     Status:  MEDLINE    
We report the case of a 19-year-old woman who developed an acute disseminated pyoderma gangrenosum (PG) during a severe flare of ulcerative colitis (UC). She was successfully treated with a 3-dose regimen of the anti-tumor-necrosis-factor-alpha antibody infliximab. The literature on the effectiveness of this biological agent was reviewed, including 8 other cases of UC-associated PG and 77 cases of Crohn's-disease-associated PG. This case report and the review of the literature demonstrate that infliximab can be successfully used to treat patients with PG associated with inflammatory bowel diseases.
Pascal Juillerat; Stephanie Christen-Zäch; François-Xavier Troillet; Suzanne Gallot-Lavallée; Renato G Pannizzon; Pierre Michetti
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  215     ISSN:  1421-9832     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  2007  
Date Detail:
Created Date:  2007-09-07     Completed Date:  2007-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  245-51     Citation Subset:  IM    
Copyright Information:
Copyright 2007 S. Karger AG, Basel.
Division of Gastroenterology and Hepatology, University of Lausanne, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
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MeSH Terms
Antibodies, Monoclonal / therapeutic use*
Colitis, Ulcerative / complications*
Dermatologic Agents / therapeutic use*
Pyoderma Gangrenosum / drug therapy*,  etiology
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Dermatologic Agents; 0/infliximab

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