| Infliximab therapy in pulmonary fibrosis associated with collagen vascular disease. | |
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MedLine Citation:
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PMID: 17417986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the potential effectiveness of tumor necrosis factor a (TNF-alpha) inhibitor treatment for pulmonary fibrosis associated with a collagen vascular disease, CVD (rheumatoid arthritis, RA and systemic sclerosis, SSc) refractory to conventional treatment. METHODS: Four patients (three men with RA, one woman with SSc) were treated with infliximab. All patients received 3mg/kgr of infliximab at intervals 0, 2 and 6 weeks, and then maintenance infusions every 8 weeks afterwards for at least a 12-month period. Patients had active disease despite treatment with corticosteroids and other immunomodulatory agents. RESULTS: Treatment was well-tolerated from all patients. Pulmonary fibrosis remained stable during treatment in terms of symptoms, pulmonary function tests (PFTs) and High resolution computed tomography (HRCT) appearance. As expected, a clinical response was observed in joint symptoms in patients with RA as evaluated by the DAS28 (Disease Activity Score, the 28 joint version). CONCLUSION: This study suggests that inhibition of TNF-alpha with infliximab may stabilize the progression of pulmonary fibrosis associated with CVD. Prospective, controlled trials are necessary to determine the efficacy of infliximab in pulmonary fibrosis associated CVD. |
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Authors:
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K M Antoniou; M Mamoulaki; K Malagari; H D Kritikos; D Bouros; N M Siafakas; D T Boumpas |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Clinical and experimental rheumatology Volume: 25 ISSN: 0392-856X ISO Abbreviation: Clin. Exp. Rheumatol. Publication Date: 2007 Jan-Feb |
Date Detail:
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Created Date: 2007-04-09 Completed Date: 2007-04-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: Italy |
Other Details:
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Languages: eng Pagination: 23-8 Citation Subset: IM |
Affiliation:
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Department of Thoracic Medicine, Clinical Immunology and Allergy, University Hospital, Medical School, University of Crete, Voutes, Heraklion, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antibodies, Monoclonal / therapeutic use* Antirheumatic Agents / therapeutic use* Arthritis, Rheumatoid / complications Female Humans Male Middle Aged Pulmonary Fibrosis / drug therapy*, etiology, radiography Respiratory Function Tests Scleroderma, Systemic / complications Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antirheumatic Agents; 0/infliximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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