| Infliximab infusion time in patients with inflammatory bowel diseases: Is longer really safer? | |
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MedLine Citation:
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PMID: 23246140 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Infliximab, a monoclonal antibody directed against tumor necrosis factor α (TNFα), is commonly used during flares and on a regular basis to maintain the remission of inflammatory bowel diseases (IBD). It is usually administered in 2-hours infusion and 2hours of monitoring after as recommended. However, recent reports suggest that infliximab infusions over a shorter period (30minutes to 1hour) are well tolerated. We aimed to compare the tolerability of 1-hour and 2-hours infliximab infusions in patients with IBD in our institution. METHODS: We analyzed data from all patients treated with infliximab between 1999 and September 2010. Infliximab was administered in 1-hour infusion and 1 hour monitoring since 2009. Only the early adverse events were analyzed. RESULTS: Adverse events during infusion were compared between one group of patients who had 1-hour infusion (989 infusions) and the other who had 2-hours infusion (2102 infusions). The incidence of adverse events was 10.6% in the 2-hours infusion group versus 6.3% in the 1-hour infusion group (P=0.36). CONCLUSIONS: These results suggest that the occurrence of infliximab infusion-related adverse events is similar across the two groups, regardless of the infusion cycle. One-hour infusion could then be proposed safely for all patients. |
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Authors:
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Mehdi Belhassan; Jean-David Zeitoun; Jérémie H Lefevre; Antoine Charachon; Aurélien Amiot; Yann Le Baleur; Iradj Sobhani; Jean-Charles Delchier |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-11 |
Journal Detail:
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Title: Clinics and research in hepatology and gastroenterology Volume: - ISSN: 2210-741X ISO Abbreviation: Clin Res Hepatol Gastroenterol Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101553659 Medline TA: Clin Res Hepatol Gastroenterol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Department of Gastroenterology, Henri-Mondor Hospital, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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