Document Detail


Infliximab-induced demyelination causes visual disturbance mistaken for recurrence of HLA-B27-related uveitis.
MedLine Citation:
PMID:  20735341     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
PURPOSE: To report a patient treated with infliximab for ankylosing spondylitis and HLA-B27 uveitis presenting with a scotoma in his left good eye due to infliximab-induced occipital demyelination mistaken for a uveitis recurrence.
DESIGN: Case report.
METHODS: Review of clinical features, visual field, and investigational procedures.
RESULTS: Loss of visual function could not be explained by mere ophthalmic examination. Magnetic resonance imaging showed several demyelinating lesions, explaining the patient's symptoms and signs. Infiliximab was discontinued and the scotoma disappeared.
CONCLUSION: This is the first report of infliximab-induced demyelination producing ocular symptoms and signs in a patient treated for uveitis.
Authors:
Marina Papadia; Carl Peter Herbort
Publication Detail:
Type:  Journal Article     Date:  2010-08-25
Journal Detail:
Title:  Ocular immunology and inflammation     Volume:  18     ISSN:  1744-5078     ISO Abbreviation:  Ocul. Immunol. Inflamm.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312169     Medline TA:  Ocul Immunol Inflamm     Country:  England    
Other Details:
Languages:  eng     Pagination:  482-4     Citation Subset:  IM    
Affiliation:
Centre for Specialized Ophthalmic Care (COS), Lausanne, Switzerland.
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Comments/Corrections
Comment In:
Ocul Immunol Inflamm. 2010 Dec;18(6):421-3   [PMID:  21091055 ]

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