Document Detail

Infliximab in Crohn's disease: first anniversary clinical experience.
MedLine Citation:
PMID:  11151879     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study is to report on the first year experience with infliximab for Crohn's disease. METHODS: All Crohn's patients receiving infliximab at our institution in the first year of release were prospectively registered. Disease activity was scored at initial infusion, and at 1, 3, 7, and 12 wk. Results were tabulated separately for patients with luminal (L) or fistulous (F) Crohn's disease. Steroid withdrawal and adverse events were tabulated. RESULTS: One hundred twenty-nine patients were treated (81 L, 48 F). Mean number of infusions/patient were 2.38 L, 3.23 F. Median time to response and remission was 8 and 9 days L; 9 and 10 days F, respectively. Initial infusion course response and remission rates at 3 wk were 65% and 31% L; 78% and 24% F, respectively. Rates were higher if concurrently treated with 6-mercaptopurine or azathioprine and improved with subsequent infusions. Relapse occurred in 78% at a mean 8.5 wk L and in 71% at a mean of 12.2 wk F. Steroid tapering was seen in >90%, with 54% completely off steroids after a second infusion. Infusion-related reactions were seen in up to 24% of patients. The incidence of side effects did not differ if on concurrent immunomodulatory therapy. CONCLUSIONS: Clinical experience with infliximab closely parallels the results of the controlled clinical trials, and includes steroid-sparing effects.
R D Cohen; J F Tsang; S B Hanauer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  95     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-09     Completed Date:  2001-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3469-77     Citation Subset:  IM    
Department of Medicine, University of Chicago Hospitals, Illinois, USA.
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MeSH Terms
6-Mercaptopurine / therapeutic use
Antibodies, Monoclonal / administration & dosage,  therapeutic use*
Azathioprine / therapeutic use
Case-Control Studies
Crohn Disease / drug therapy,  therapy*
Gastrointestinal Agents / administration & dosage,  therapeutic use*
Prednisone / therapeutic use
Prospective Studies
Time Factors
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Gastrointestinal Agents; 0/infliximab; 446-86-6/Azathioprine; 50-44-2/6-Mercaptopurine; 53-03-2/Prednisone

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